Intracellular trafficking of viruses and proteins commonly occurs via the early endosome in a process involving Rab5. The RNA Import Complex (RIC)-RNA complex is taken up by mammalian cells and targeted to mitochondria. Through RNA interference, it was shown that mito-targeting of the ribonucleoprotein (RNP) was dependent on caveolin 1 (Cav1), dynamin 2, Filamin A and NSF. Although a minor frac...

The inflammatory response to Pseudomonas aeruginosa is not properly regulated in the lungs of patients with cystic fibrosis (CF). In the lung epithelium of individuals with wild-type CF transmembrane conductance regulator, lipid rafts containing CF transmembrane conductance regulator are rapidly formed in response to P. aeruginosa infection, and this response is closely linked to resistance to ...

Caveolins (CAVs) constitute a family of proteins that are principally responsible for the formation of caveolae, flaskshaped invaginations of the plasma membrane. Currently, there are three known caveolins: caveolin-1(CAV1), caveolin-2(CAV2), and caveolin-3 (CAV3). CAV1 was the first of the CAVs to be discovered (originally cloned as VIP21 in canines) [1]. CAV1 is an integral membrane protein t...

Extracellular S3-S4 linkers of domain IV (IVS3-S4) of L-type Ca2+ channels (CaV1) are subject to alternative splicing, resulting into distinct gating profiles serving for diverse physiological roles. However, it has remained elusive what would be the determining factor of IVS3-S4 effects on CaV1 channels. In this study, we systematically compared IVS3-S4 variants from CaV1.1-1.4, and discover t...

Integrin-mediated adhesion regulates cellular responses to changes in the mechanical and biochemical properties of extracellular matrix. Cell–matrix caveolar endocytosis, dependent on caveolin 1 (Cav1) Tyr14 phosphorylation (pY14Cav1), control anchorage-dependent signaling. We find that cell–matrix pY14Cav1 levels mouse fibroblasts. Biochemical fractionation reveals endogenous be present caveol...

CONTEXT Caveolin-1 (CAV1) is an inhibitor of tissue fibrosis. OBJECTIVE To study the association of CAV1 gene variation with kidney transplant outcome, using kidney transplantation as a model of accelerated fibrosis. DESIGN, SETTING, AND PATIENTS Candidate gene association and validation study. Genomic DNA from 785 white kidney transplant donors and their respective recipients (transplantat...

Pancreas transplantation is a successful treatment for a selected group of people with type 1 diabetes. Continued insulin production can decrease over time and identifying predictors of long-term graft function is key to improving survival. The aim of this study was to screen subjects for variation in the Caveolin-1 gene (Cav1), previously shown to correlate with long-term kidney transplant fun...

In Parkinson’s disease oxidative stress and calcium-induced excitotoxicity have been considered important mechanisms leading to cell death for decades, but the factors that make some neurons vulnerable to neurodegeneration while others remain resistant are not fully understood. Studies of the disorder in animal models suggest that the voltage-gated calcium channel subtype CaV1.3 has a role in m...

Angiogenesis is the result of the combined activity of the tumor microenvironment and signaling molecules. The angiogenic switch is represented as an imbalance between pro- and anti-angiogenic factors and is a rate-limiting step in the development of tumors. Eph receptor tyrosine kinases and their membrane-anchored ligands, known as ephrins, constitute the largest receptor tyrosine kinase (RTK)...

PURPOSE The human CAV1-CAV2 locus has been associated with susceptibility to primary open-angle glaucoma in four studies of Caucasian, Chinese, and Pakistani populations, although not in several other studies of non-Korean populations. In this study with Korean participants, the CAV1-CAV2 locus was investigated for associations with susceptibility to primary open-angle glaucoma accompanied by e...