CD38, as a cell surface antigen is highly expressed in several hematologic malignancies including multiple myeloma (MM) and has been proven to be a good target for immunotherapy of the disease. CD38 is also a signaling enzyme responsible for the metabolism of two novel calcium messenger molecules. To be able to target this multifunctional protein, we generated a series of nanobodies against CD3...

CD38, a surface glycoprotein of unrestricted lineage, is an ectoenzyme (adenosine diphosphate [ADP] ribosyl cyclase/cyclic ADP-ribose hydrolase) that regulates cytoplasmic calcium. The molecule also performs as a receptor, modulating cell-cell interactions and delivering transmembrane signals, despite showing a structural ineptitude to the scope. CD38 ligation by agonistic monoclonal antibodies...

Human CD38 is a 45-kDa type II membrane glycoprotein with an intricate pattern of expression in leukocytes, although evidence is accumulating of its quite widespread expression in cells of nonvascular origin. CD38 is a member of a nascent eukaryotic gene family encoding cytosolic and membrane-bound enzymes whose substrate is NAD, a coenzyme ubiquitously distributed in nature. Functionally, CD38...

Clonal evolution and outgrowth of cellular variants with additional chromosomal abnormalities are major causes of disease progression in chronic lymphocytic leukemia (CLL). Because new DNA lesions occur during S phase, proliferating cells are at the core of this problem. In this study, we used in vivo deuterium ((2)H) labeling of CLL cells to better understand the phenotype of proliferating cel...

We have previously found that the synthetic polyamine tetraethylenepentamine (TEPA) significantly delayed differentiation and prolonged expansion of cord-blood derived HPC in cytokine-supplemented cultures. Most HPC have the CD34+CD38+ phenotype, but the minority CD34+38- cells are primitive subset of HPC that have the potential for long-term repopulation in vivo. We investigated the effect of ...

UNLABELLED Serum thymidine kinase (TK), zeta-associated protein of 70 kDa (ZAP-70) and CD38 levels have been shown to be correlated with survival in chronic lymphocytic leukaemia (CLL). AIM To investigate the possible correlations between TK, ZAP-70 and CD38 levels as prognostic markers in new diagnosed Rai stages of CLL patients. METHODS 120 CLL patients were enrolled. ELISA was used to me...

Cyclic ADP-ribose (cADPR) has been shown to be a mediator for intracellular Ca 2 1 mobilization for insulin secretion by glucose in pancreatic b cells, and CD38 shows both ADP-ribosyl cyclase to synthesize cADPR from NAD 1 and cADPR hydrolase to hydrolyze cADPR to ADP-ribose. We show here that 13.8% of Japanese non–insulin-dependent diabetes (NIDDM) patients examined have autoantibodies against...

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes that escape death, and correlates with expression negative prognostic markers such as CD38 antigen. Although certain new drugs approved US Food Drug Administration improve clinical outcome CLL patients, drug resistance disease relapse still occur. Like CD38, neutrophil gelatinase-associated lipoc...

We have read with interest the report of Goldmacher et al.’ They describe the construction of an anti-CD38 imunotoxin (IT) by conjugating CD38 monoclonal antibody (MoAb) HB7 to blocked ricin. The resulting IT shows potent killing of plasma cell lines, whereas only low toxicity is observed for hematopoietic precursor cells (HPC). Therefore, they conclude that this HB7-blocked ricin may have clin...

background: patients with b-cell chronic lymphocytic leukemia (b-cll) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome. recent immunophenotypic stud-ies performed mainly in western populations have demonstrated the prognostic value of cd38 and zap-70 expression in b-cll. objectives: to i...