نتایج جستجو برای: cd64
تعداد نتایج: 573 فیلتر نتایج به سال:
Syphilis is a multi-stage, sexually transmitted disease caused by the spirochete Treponema pallidum (Tp). Considered broadly, syphilis can be conceptualized as a dualistic process in which spirochete-driven inflammation, the cause of clinical manifestations, coexists to varying extents with bacterial persistence. Inflammation is elicited in the tissues, along with the persistence of spirochetes...
1 Bone marrow aspirate and trephine biopsy unless the peripheral blast count is high. 2 Immunophenotyping [CD3, CD7, CD13, CD14, CD33, CD34, CD64, CD117 and cytoplasmic myeloperoxidase (MPO)]. 3 Cytochemistry (MPO or Sudan Black, combined esterase). Can be omitted if four-colour flow cytometry is available. 4 Cytogenetics [with reverse-transcription polymerase chain reaction (RT-PCR) for AML 1-...
Bispecific anti-CD33×anti-CD64 antibody (BsAb) directly inhibited proliferation and colony formation of human acute myeloid leukemia cell lines, without affecting the function of normal monocytes. Addition of BsAb to normal monocytes induced tyrosine phosphorylation of Cbl and Vav, association of these molecules with CD33, and downstream signaling. In leukemia cells that were insensitive to BsA...
In this study we have examined hFcyRl expression during myelopoiesis. Normal bone marrow (BM) cells were found to express hFcyRl up to the metamyelocyte stage. A different FcyRl expression pattern was observed in an in vitro model of myelopoiesis. Purified CD34-positive BM cells, cultured for 12 to 14 days with granulocyte colony-stimulating factor (G-CSF), differentiate into a population of ma...
Background Monoclonal antibodies targeting the interleukin (IL)-23p19 subunit are effective in treatment of psoriatic disease but have different molecular attributes that may translate to differences clinical efficacy. Within this class, guselkumab (GUS) is a fully human IgG1 monoclonal antibody with native Fc region, while risankizumab (RIS) humanised mutated region. Binding these therapeutic ...
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