Among the diverse picture of preeclampsia, hematological component, thrombocytopenia, attracts attention. Platelets are able to form microvesicles by budding plasma membrane from cell surface during apoptosis, stimulation, and also in a small amount normal conditions. The these particles has negative charge contains phospholipids an integral glycoprotein on outer monolayer, due which platelet i...

The human melanoma cell line M24met expresses tissue factor, the cellular initiator of the blood coagulation cascade. Blocking of the coag ulation pathways at the level of tissue factor, factor Xa, or thrombin inhibits hematogenous M24met metastasis in SCID mice, implicating a role for thrombin generation in this process. Dependent on cell surface tissue factor activity, M24met cells generate t...

hemiscorpius lepturus belonging to hemiscorpiidae family is the most venomous of all types of scorpion existing in south west of iran causing hemoglobinuria and dermal lesions by envenomation. we compare the hemolytic pattern upon time in different domestic animals upon time according to their different sphingomyelin contents. in addition other in vitro hematologic parameters, platelet lysis, c...

A small, noninjurious dose of bacterial lipopolysaccharide (LPS; 7.4 x 106 EU/kg) administered 4 h after a small, nontoxic dose of monocrotaline (MCT; 100 mg/kg) produces synergistic hepatotoxicity in rats within 6 to 12 h after MCT exposure. The resulting centrilobular (CL) and midzonal (MZ) liver lesions are characterized by hepatic parenchymal cell (HPC) necrosis. Pronounced hemorrhage, disr...

groundwater makes up an important part of global freshwater resources, though it is often threatened by overuse of natural resources along with abundant production of wastes in modern society. this study aims to investigate the removal of three heavy metals including nickel, cadmium, and lead from groundwater via electrocoagulation, a suitable method for treatment of water-soluble compounds, de...

Background:  Human coagulation factor IX (hFIX) is a glycoprotein with two N-glycosylation sites at the activation peptide. Since the activation peptide is removed in mature hFIX, the exact role of N-glycosylation is unclear. To investigate the role of N-glycosylation in the secretion and activity of hFIX, we inhibited N-glycosylation by tunicamycin in the stable Human Embryonic Kidney (HEK)- c...