The triad of keratoconjunctivitis sicca (KCS), salivary gland involvement (increase in size or xerostomia), and rheumatoid arthritis was described by Sjogren (1933) as a rare syndrome. Any two of the triad were sufficient to make the diagnosis. Subsequently the syndrome has been extended to include disseminated lupus erythematosus (Morgan, 1954; Ramage and Kinnear, 1956; Bain, 1960), systemic s...

Staphylokinase is a highly fibrin-specific clot-dissolving agent that constitutes a promising drug for clinical development. It is of bacterial origin, and the majority of patients develop neutralizing Ab after its administration. Several antigenic regions, recognized by these Ab, have been identified, but the underlying immunogenic features of staphylokinase remain unknown. In this study, we s...

Previous studies on antisperm cell-mediated immunity (CMI) have been confounded by the presence of immunogenic leukocytes in sperm antigen preparations. In this study we isolated pure populations of viable spermatozoa on discontinuous Percoll gradients, and utilized sonicated and cavitated extracts, as well as live motile spermatozoa, to measure cellular immunity to spermatozoa in vasectomized ...

Specific immunologic resistance mechanisms to cytomegalovirus (CMV) have not been extensively studied in either normal subjects or immunosuppressed renal allograft recipients. Such studies are in progress in my laboratory. Humoral immunity to CMV appears to be unimpaired in infected transplant patients. The neutralizing (NT) antibody titers in 24 allograft recipients with active CMV infection w...

The microsporidia are obligate intracellular parasites that were previously thought to be ‘‘primitive’’ eukaryotes, but which are now recognized to be either related to or a sister group to the Fungi [1]. These protists are relatively common enteric pathogens that usually result in self-limited or asymptomatic infections in humans. Microsporidia were initially recognized as pathogens causing pé...

yields to the advances of a man, to the inevitable biological process of pregnancy, or to inner feelings or urges she loses control. I do not think it is easy for a woman to talk about losing control, and certainly these feelings would not be elicited by questions delivered briskly as a patellar hammer eliciting tendon jerks. With skilled interviewing some of these women might talk about drop a...

The discovery of the molecular nature of T cell-mediated immunity is reviewed in a historical context. Current approaches to understanding virus-induced inflammatory processes are described.