نتایج جستجو برای: cell penetrating peptides

تعداد نتایج: 1749706  

Journal: :Nucleosides, nucleotides & nucleic acids 2015
Bhanu P Pemmaraju Swapnil Malekar Hitesh K Agarwal Rakesh K Tiwari Donghoon Oh Gustavo F Doncel David R Worthen Keykavous Parang

The objective of this work was to design conjugates of anti-HIV nucleosides conjugated with fatty acids and cell-penetrating poly-L-arginine (polyArg) peptides. Three conjugates of polyArg cell-penetrating peptides with fatty acyl derivatives of alovudine (FLT), lamivudine (3TC), and emtricitabine (FTC) were synthesized. In general, the compounds exhibited anti-HIV activity against X4 and R5 ce...

2016
Junxiao Ye Ergang Liu Zhili Yu Xing Pei Sunhui Chen Pengwei Zhang Meong-Cheol Shin Junbo Gong Huining He Victor C. Yang

For the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally originated penetrating enhancers, help overcome the membrane barrier that has hindered the access of bio-macromolecular compounds such as genes and proteins into cells, thereby denying their clinical potential to become potent anti-cancer drugs. B...

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