نتایج جستجو برای: cellular senescence
تعداد نتایج: 453587 فیلتر نتایج به سال:
Senescent melanocytes accumulate in photoaged skin and are closely related to aging. A better understanding of molecular characteristics senescent might be a key controlling We have developed an vitro model senescence using UV irradiation highlighted that characterized by melanosome transfer dysfunction resulting melanin accumulation. The defective transport was confirmed with ultrastructural c...
Cellular senescence arrests the proliferation of mammalian cells at risk for neoplastic transformation, and is also associated with aging. However, the factors that cause cellular senescence during aging are unclear. Excessive reactive oxygen species (ROS) have been shown to cause cellular senescence in culture, and accumulated molecular damage due to mitochondrial ROS has long been thought to ...
The tracking of cellular senescence usually depends on the detection senescence-associated β-galactosidase (SA-β-gal). Previous probes for SA-β-gal with this purpose only cover a single dimension: accumulation enzyme in lysosomes. However, is insufficient to determine destiny because endogenous β-gal enriched lysosomes not related senescence, but also some other physiological processes. To addr...
Cellular senescence is post-mitotic or oncogene-induced events combined with nuclear remodeling. MCAF1 (also known as hAM or ATF7IP), a transcriptional cofactor that is overexpressed in various cancers, functions in gene activation or repression, depending on interacting partners. In this study, we found that MCAF1 localizes to PML nuclear bodies in human fibroblasts and non-cancerous cells. In...
Autophagy, a process that helps maintain homeostatic balance between the synthesis, degradation, and recycling of organelles and proteins to meet metabolic demands, plays an important regulatory role in cellular senescence and differentiation. Here we examine the regulatory role of autophagy in idiopathic pulmonary fibrosis (IPF) pathogenesis. We test the hypothesis that epithelial cell senesce...
The p53 tumor suppressor plays a key role in organismal aging. A cellular mechanism postulated to drive the aging process is cellular senescence, mediated in part by p53. Although senescent cells accumulate in elderly individuals, most studies have relied on correlating in vitro senescence assays with in vivo phenotypes of aging. Here, using two different mouse models in which the p53-related p...
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