BACKGROUND AND PURPOSE We performed a double-blind, placebo-controlled study to investigate the effectiveness of amitriptyline for the prophylactic treatment of patients with acute thalamic stroke in preventing central poststroke pain. METHODS Subject received, in a randomized sequence, either amitriptyline titrated from 10 to 75 mg in extended-release form or placebo over a therapy period of...

This prospective study was undertaken to determine the incidence of post obturation pain related to root canal treatment of asymptomatic non-vital maxillary central incisor teeth that were prepared and filled in one visit using two different manual rootcanal preparation techniques: the step-back and the step-down and to determine the relationship, if any between post obturation pain and root ca...

A post-marketing surveillance study of gabapentin usage in Filipino patients with neuropathic pain was conducted. Safety, tolerability and analgesic efficacy were assessed after a minimum of two weeks of gabapentin treatment, with starting and final doses determined by the prescribing physician. Of the 1,214 patients who entered the study, 95.7% completed the minimum two weeks duration of thera...

BACKGROUND Central pain syndrome is characterized by a combination of abnormal pain sensations, and pain medications often provide little or no relief. Accumulating animal and clinical studies have shown that impairments of the spinothalamic tract (STT) and thalamocingulate pathway causes somatosensory dysfunction in central post-stroke pain (CPSP), but the involvement of other neuronal circuit...