The genetic pathways that partition the developing nervous system into functional systems are largely unknown. The engrailed (En) homeobox transcription factors are candidate regulators of this process in the dorsal midbrain (tectum) and anterior hindbrain (cerebellum). En1 mutants lack most of the tectum and cerebellum and die at birth, whereas En2 mutants are viable with a smaller cerebellum ...

Zika virus (ZIKV) disease continues to be a threat public health, and it is estimated that millions of people have been infected there more cases serious complications than those already reported. Despite many studies on the pathogenesis ZIKV, several genes involved in malformations associated with viral infection are still unknown. In this work, morphological molecular changes cortex cerebellu...

Associative learning is thought to require coordinated activities among distributed brain regions. For example, to direct behavior appropriately, the medial prefrontal cortex (mPFC) must encode and maintain sensory information and then interact with the cerebellum during trace eyeblink conditioning (TEBC), a commonly-used associative learning model. However, the mechanisms by which these two di...

Evidence from neuroimaging and cerebellar lesion studies indicate that the cerebellum plays a role in language articulation and verbal fluency. Previous studies have established that distinct areas of the cerebellum are differentially active during each of these tasks, with articulation engaging the anterior cerebellum and verbal fluency activating areas of the right posterolateral cerebellum. ...