Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the degeneration of upper motor neurons in brainstem and spinal cord lower neurons. ALS was first described Jean-Martin Charcot 1874 based on clinical features postmortem examinations. In 1990, diagnostic criteria for were developed features. Subsequently, three additional published. this article, we...

P roinflammatory changes in the immune phenotype of circulating blood monocytes in acute Charcot in diabetes have recently been described (1), but the effects of immunosuppression have not been investigated. This report describes a modified clinical phenotype for Charcot in three subjects on immunosupression therapy for previous transplantation—two live-related renal and one simultaneous pancre...