BACKGROUND Activation of hepatic CB(1) receptors (CB(1)) is associated with steatosis and fibrosis in experimental forms of liver disease. However, CB(1) expression has not been assessed in patients with chronic hepatitis C (CHC), a disease associated with insulin resistance, steatosis and metabolic disturbance. We aimed to determine the importance and explore the associations of CB(1) expressi...

MicroRNAs are messengers during interferon-virus interplay and are involved in antiviral immunity, however, little is known about interferon-related microRNAs regarding their detection in serum and their potential use as non-invasive diagnostic and prognostic biomarkers in chronic hepatitis C (CHC). To elucidate some of the molecular aspects underlying failure of pegylated interferon-α/ribaviri...

Although the traditional role of clathrin has been in vesicle trafficking and the internalization of receptors, a novel role in cytokinesis was recently revealed in an analysis of a clathrin-minus Dictyostelium mutant (chc(-)). chc(-) cells grown in suspension were demonstrated to be defective in assembling myosin II into a normal contractile ring. To test whether this defect reflected a more g...

background il-33 is a novel member of the il-1 family, which has been shown to play an important role in t helper 2 (th2)-associated immune responses. recent studies have suggested a possible role for il-33 in the pathogenesis of liver damage during acute and chronic hepatitis; furthermore, il-33 may be involved in the development and progression of liver fibrosis. objectives to evaluate serum ...

Cuticular hydrocarbons (CHCs) are utilized by insects for a variety of physiological and communicative purposes. Social insects have capitalized on the vast potential of CHCs as an information source, using them as signals to regulate social interactions. Currently, only female CHC profiles have been explored, and little is known regarding the CHC profiles of males. Here, using Polistes dominul...

OBJECTIVES In 2008 and 2013, the University of Massachusetts Medical School and the Massachusetts League of Community Health Centers surveyed community health center (CHC) primary care physicians (PCPs) to identify factors related to preparedness, recruitment and retention. The survey was repeated to determine the impact of Massachusetts health care reform. METHODS An online survey was sent t...

Obesity in chronic hepatitis C (CHC) is associated with adverse hepatic and metabolic outcomes. This prospective study evaluates the agreement between self-perceived body weight (BW) status and measured body mass index (BMI) category and factors associated with its underestimation in CHC. Body size perception was measured with the Contour Drawing Rating Scale. Two hundred and seventy-three pati...

This article reviews factor-analytic research on individually administered intelligence tests from a Cattell–Horn–Carroll (CHC) perspective. Although most new and revised tests of intelligence are based, at least in part, on CHC theory, earlier versions generally were not. Our review suggests that whether or not they were based on CHC theory, the factors derived from both new and previous versi...

Abstract Many problems in program verification, Model Checking, and type inference are naturally expressed as satisfiability of a verification condition fragment First-Order Logic called Constrained Horn Clauses (CHC). This transforms analysis tasks to the realm first order into SMT solvers. In this paper, we give brief overview how CHCs capture for sequential imperative programs, discuss CHC s...

A heuristic technique that combines a genetic algorithm with a Tabu Search algorithm is applied to the Quadratic Assignment Problem (QAP). The hybrid algorithm improves the results obtained through the application of each of these algorithms separately. The QAP is a NP-hard problem and instances of size n > 15 are still considered intractable. The results of our experiments suggest that CHC com...