نتایج جستجو برای: chelerythrine

تعداد نتایج: 636  

2015
Jongsun Yu Seong-Ho Ok Won Ho Kim Hyunhoo Cho Jungchul Park il-Woo Shin Heon Keun Lee Young-Kyun Chung Mun-Jeoung Choi Seong-Chun Kwon Ju-Tae Sohn

Vasoconstriction mediated by the highly selective alpha-2 adrenoceptor agonist dexmedetomidine leads to transiently increased blood pressure and severe hypertension. The dexmedetomidine-induced contraction involves the protein kinase C (PKC)-mediated pathway. However, the main PKC isoform involved in the dexmedetomidine-induced contraction remains unknown. The goal of this in vitro study was to...

Journal: :American journal of physiology. Renal physiology 2007
Anees Ahmad Banday Fatima Rizwan Fazili Mustafa F Lokhandwala

The renal dopamine system plays an important role in sodium homeostasis and a defect in dopamine D1 receptor (D1R) function is present in hypertension, diabetes, and aging. Our previous studies in hyperinsulinemic animals and in renal cell cultures treated with insulin showed decrease in D1R number and defective coupling to G proteins; however, the exact mechanisms remained unknown. Therefore, ...

2016
XIAO-MENG CHEN MENG ZHANG PENG-LI FAN YU-HUA QIN HONG-WEI ZHAO

Previous studies have demonstrated that the benzo[c]phenanthridine alkaloid chelerythrine chloride (CC) has inhibitory effects on various tumors. However, the anticancer activity of CC and its underlying mechanisms have not been elucidated in renal cancer cells. The present study examined the effects of CC on growth inhibition and apoptosis of renal cancer cells in vitro and in vivo. Flow cytom...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Greg Villareal Quan Li Diancai Cai Ann E Fink Travis Lim Joanna K Bougie Wayne S Sossin David L Glanzman

Serotonin (5-HT) mediates learning-related facilitation of sensorimotor synapses in Aplysia californica. Under some circumstances 5-HT-dependent facilitation requires the activity of protein kinase C (PKC). One critical site of PKC's contribution to 5-HT-dependent synaptic facilitation is the presynaptic sensory neuron. Here, we provide evidence that postsynaptic PKC also contributes to synapti...

Journal: :American journal of physiology. Heart and circulatory physiology 2006
Karin Przyklenk Michelle Maynard Peter Whittaker

Prophylactic treatment with D-myo-inositol 1,4,5-trisphosphate hexasodium [D-myo-Ins(1,4,5)P3], the sodium salt of the endogenous second messenger Ins(1,4,5)P3, triggers a reduction of infarct size comparable in magnitude to that seen with ischemic preconditioning (PC). However, the mechanisms underlying D-myo-Ins(1,4,5)P3-induced protection are unknown. Accordingly, our aim was to investigate ...

2003
Melissa A. Fleegal Colin Sumners

Fleegal, Melissa A., and Colin Sumners. Drinking behavior elicited by central injection of angiotensin II: roles for protein kinase C and Ca2 /calmodulin-dependent protein kinase II. Am J Physiol Regul Integr Comp Physiol 285: R632–R640, 2003. First published May 8, 2003; 10.1152/ ajpregu.00151.2003.—Prior studies utilizing neurons cultured from the hypothalamus and brain stem of newborn rats h...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Jan Neckár Irena Marková Frantisek Novák Olga Nováková Ondrej Szárszoi Bohuslav Ost'ádal Frantisek Kolár

We examined the role of protein kinase C (PKC) in the cardioprotective mechanism induced by long-term adaptation to chronic intermittent hypoxia. Adult male Wistar rats were exposed to hypobaric hypoxia of 7,000 m for 8 h/day, 5 days/wk; the total number of exposures was 24-32. A control group was kept under normoxic conditions. Western blot analysis of PKC isoforms-delta and -epsilon was perfo...

Journal: :The Journal of Physiology 2009
Sohag N Saleh Anthony P Albert William A Large

In the present study the effect of phosphatidylinositol 4,5-bisphosphate (PIP(2)) was studied on a native TRPC1 store-operated channel (SOC) in freshly dispersed rabbit portal vein myocytes. Application of diC8-PIP(2), a water soluble form of PIP(2), to quiescent inside-out patches evoked single channel currents with a unitary conductance of 1.9 pS. DiC8-PIP(2)-evoked channel currents were inhi...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Zhiping Cao Lijuan Liu Donna M Van Winkle

Our previous studies indicated that opioid-induced cardioprotection occurs via activation of mitochondrial ATP-sensitive K(+) (K(ATP)) channels. However, other elements of the Met(5)-enkephalin (ME) cardioprotection pathway are not fully characterized. In the present study, we investigated the role of tyrosine kinase, MAPK, and phosphatidylinositol 3-kinase (PI3K) signaling in ME-induced protec...

Journal: :The Journal of pharmacology and experimental therapeutics 2002
Hong Yan Zhang Bradley C McPherson Huiping Liu Timir Baman Steven S McPherson Peter Rock Zhenhai Yao

Opioids generate free radicals that mediate protection in isolated cultured cardiomyocytes. We hypothesize that the nature of these radicals is nitric oxide, and that nitric oxide activates the protein kinase C (PKC) delta isoform. Through this signal transduction pathway, opiates protect cardiomyocytes during hypoxia and reoxygenation. Cell viability was quantified in chick embryonic ventricul...

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