Long-course chemo-radiotherapy (45~50 Gy in 25 fractions) with delayed surgery or short-course radiotherapy (25 Gy in 5 fractions) with immediate surgery were the most frequent regimens for the treatment of localized and locally advanced resectable rectal cancer (SWEDISH RECTAL CANCER TRIAL, 1997; Colorectal Cancer Collaborative Group, 2001; Kapiteijn et al., 2001; Sauer et al., 2004). Compared...

Abstract The palladium-catalysed cyclisation of propargylic electrophiles with nucleophiles represents a useful synthetic approach for the rapid construction heterocyclic building blocks. However, these reaction processes often pose number challenges due to need simultaneous control chemo-, regio- and stereoselectivity. Herein, we disclose discovery ?-amido malonates as novel bis-nucleophiles i...

The case of a 16-year-old boy is reported who underwent surgery for the excision of an Askin tumor and has subsequently undergone six excisions of local Askin tumor recurrences, with follow-up postoperative chemo- and radiotherapy over a 7-year period. The patient continues to survive. As far as can be determined, this patient appears to be the first reported case of long-term survival after re...

Microfluidic devices can be molded easily from PDMS using soft lithography. However, the softness of the resulting microchannels makes it difficult to photolithographically pattern their surface properties, as is needed for applications such as double emulsification. We introduce a new patterning method for PDMS devices, using integrated oxygen reservoirs fabricated simultaneously with the micr...

Table 1. Drug Acquisition, Administration, and Monitoring Costs for FirstLine Treatment With OChl and Chl Cost Type OChl Chl Drug acquisition Ofatumumab, 100 mg vial $336 – Chlorambucil, 25 x 2 mg pack $35 $35 Administration Induction infusion in first cycle (O) $1,039 – Regular infusion in subsequent cycles (O) $818 – Oral chemotherapy dispensing (Chl)a $9 $9 Monitoring (per chemo cycle)b $119...

Autologous stem cell transplant remains the standard of care for relapsed Hodgkin lymphoma (HL). Approximately 50% of patients with chemo-sensitive relapse will be cured with this approach. The optimal pretransplant salvage regimen is controversial, but less toxic combinations seem to be equivalent to more aggressive approaches. For patients with chemo-refractory disease at relapse and those fa...

A 53-year-old man underwent neo-adjuvant chemo-radiotherapy and a 2 stage oesophagectomy for a junctional oesophageal tumour in 1996. In March 2012, a metachronous oesophageal tumour was identified, 7cm above the anastomotic margin, on a background of non-inflamed squamous mucosa. He is currently being managed with chemo-radiotherapy. Oesophageal cancer is associated with a historically poor su...

A new Chemo – Dynamical Smoothed Particle Hydrodynamic (CD – SPH) code is presented. The disk galaxy is described as a multi – fragmented gas and star system, embedded into the cold dark matter halo. The star formation (SF) process, SNII, SNIa and PN events as well as chemical enrichment of gas have been considered within the framework of standard SPH model. Using this model we try to describe ...

The risk of human breast cancer is concerned to cumulative exposure of the breast cells to endogenous estrogens. Strategies aiming at reducing the production of estrogens may be useful for the prevention of estrogens-related breast cancer. Several natural products with plant origin have the potential value as chemo-preventive or therapeutic agents in cancer. Flavonoids, the natural polyphenol c...

The dirhodium caprolactamate [Rh(2)(cap)(4)] catalyzed oxidation of secondary amines to imines by tert-butyl hydroperoxide (TBHP) occurs with high chemo- and regioselectivity.