Abstract Histone 3 lysine27-to-methionine mutations (H3-K27M) frequently occur in childhood diffuse midline gliomas (DMGs) of the pons, thalamus, and spinal cord, presumed to be driven by specific spatiotemporal context these locations during postnatal development. While most common pons at mid-childhood ages, same oncohistone mutation is recurrently detected adult DMGs throughout different reg...

The granulosa cell tumor is the most common malignant functioning tumor of the ovary. When functional, granulosa tumor almost always are estrogenic although rare tumors are androgenic. Progesterone producing by these tumors has only been reported twice. We report a case of granulosa cell tumor in a 7 years old girl with precocious puberty who represent the first case of progesterone producing b...

Craniopharyngioma are the most common non-glial tumors in childhood. The results of different studies indicate that radical excision surgery is not an appropriate treatment strategy for childhood craniopharyngioma with hypothalamic involvement. Stereotactic neurosurgery provides save, minimal invasive and cost-efficient options in the treatment of childhood craniopharyngioma. In this review a s...

Abstract Background: Abdominal tumors are still a diagnostic problem in children. This study was conducted to assess the presentation and types of childhood intra abdominal tumors in children in Shiraz. Materials and Methods: Participants of this historical cohort study consisted of 298 children aged between 1.5 months to 15 years old who were diagnosed with abdominal mass between March...

Brain tumors are the second most common cancer in children after leukemia, yet the etiology of childhood brain tumors remains unknown. Tobacco smoke contains several dozen compounds that are known to be carcinogens. Among these are N-nitroso compound precursors, principally tobacco-specific nitrosamines. Although smoking has not been identified as a significant risk factor for the development o...

BACKGROUND The peak incidence of central nervous system (CNS) tumors in childhood indicates that intrauterine or neonatal characteristics are potential risk factors or symptoms of early onset of disease. METHODS We conducted a registry-based case-control study nested in the childhood populations of Denmark, Finland, Sweden, and Norway on the association between indicators of fetal growth and ...

INTRODUCTION In spite of its low incidence, childhood cancer is becoming increasingly more relevant in Argentina. More advances have been made in cancer treatment than in the study of its etiology or determining factors. There are no investigations that analyze its spatial and temporal distribution or potential clustering. OBJETIVE To perform exploratory spatial and temporal analyses based on...

conclusions carcinomas were the most common malignant tumors of head and neck observed in this age group. also, oral cancers in children and adolescents constitute a small percentage of the lesions that were studied objectives we aimed to determine the frequency of head and neck cancers in a population of iranian children and adolescents. patients and methods the records of patients ≤ 19 years ...

Brain tumors are the second most common group of childhood cancers, accounting for about 20%-25% of all pediatric tumors. Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of these neoplasms, and their expression levels are often correlated with poor prognosis. Elevated c-MYC/MYCN initiates and drives tumorigenesis in ma...

During the past 3 decades, chemotherapeutic agents for the treatment of pediatric brain tumors have been extensively evaluated in a myriad of schedules, doses, and combinations. Remarkable advances in outcome have been achieved for certain children, notably those with medulloblastoma, but with a high cost to quality of life. In addition, the success achieved for medulloblastoma is offset by lac...