Jung-Seok Han, Kyung-Rae Dong, Yong-Soon Park, Woon-Kwan Chung*, Jae-Hwan Cho, and Young-Kuk Cho Depatment of Nuclear Medicine, Asan Medical Center, Seoul 138-736, Korea Department of Radiological Technology, Gwangju Health College University, Gwangju 506-701, Korea Department of Nuclear Engineering, Chosun University, Gwangju 501-759, Korea 4 Department of International Radiological Science, H...

The ability of heparan sulfate, heparin, and other glycosaminoglycans to inhibit the infectivity of Chlamydia trachomatis serovars E and LGV was examined using a simple competitive inhibition assay with three cell types from the human female reproductive tract, including primary human endosalpingeal cells. With the majority of the glycosaminoglycans tested, LGV was more significantly inhibited ...

We constructed an assay system for the rapid detection of the glycosylation status of antibodies with a chemiluminescence-based lectin-binding assay, and investigated the glycosylation dynamics during the culture of recombinant Chinese hamster ovary cells. This rapid detection system is applicable to the high-throughput evaluation of therapeutic glycoproteins.

A new multiple drug-resistant Chinese hamster ovary cell line, ( IK )SMRs, has been isolated which demonstrates a direct correlation between reduced cellular topoisomerase II activity (5-fold reduction) and a low level of resistance (3to 7-fold) to topoisomerase II inhibitors. This cell line, initially selected for resistance to 9-(4,6-0-ethylidene-i8-D-glucopyranosyl)-4'-demethylepipodophyllot...

Nitromidazole and nitrofuran derivatives comprise a large family of compounds, some of which have been shown to be hypoxic cell specific radiosensitizers in vivo and in vitro. The effects of metronidazole (2-methyl-5-nitroimidazole-1-ethanol) and nitrofurazone (5-nitro-2-furaldehyde semicarbazone) were studied on cell viability in vitro in the presence of air or nitrogen in the absence of radia...

A series of observations have indicated that tau, one of the major microtubule-associated proteins, is involved in neuronal cell morphogenesis and axonal maintenance. Tau is also the major component of paired helical filaments found in brains affected by Alzheimer's disease. To explore an as yet unidentified role of tau in vivo, approximately 11,000 mRNAs were profiled from tau-deficient mouse ...