Fast-gelling chitosan thermosensitive hydrogels have proven to be excellent matrices for targeted drug-delivery and cell therapy. In this work, we demonstrate the possibility of designing injectable bioadhesive with a high gelation rate by modifying catechol (cat-CH) using sodium bicarbonate (SHC) as gelling agent. Cat-CH/SHC gel under 5 min at 37 °C reach secant modulus after 24 h (E = 90 kPa ...

Chitosan is the N-deacetylated derivative of chitin, a naturally abundant mucopolysaccharide that consists of 2-acetamido-2-deoxy-β-d-glucose through a β (1→4) linkage and is found in nature as the supporting material of crustaceans, insects, etc. Chitosan has been strongly recommended as a suitable functional material because of its excellent biocompatibility, biodegradability, non-toxicity, a...

Recent developments in tissue engineering approaches frequently revolve around the use of three-dimensional scaffolds to function as the template for cellular activities to repair, rebuild and regenerate damaged or lost tissues. While there are several biomaterials to select as three-dimensional scaffolds, it is generally agreed that a biomaterial to be used in tissue engineering needs to posse...

To establish a gold/silica hybrid, nanomaterials (Au/SiO2) were incorporated into gelatin methacrylate/chitosan matrix. By using FESEM, compressive strength testing, and conductivity/resistance measurements on (G)/chitosan (C), G/C-Au@SiO2 hydrogels developed. Biocompatibility investigations osteoblasts MG-63 cells carried out to determine whether the cell was compatible with conductive hydroge...

The design of improved biopolymeric based hydrogel materials with high load-capacity to serve as biocompatible drug carriers is a challenging task vital implications in health sciences. In this work, chitosan crosslinked dialdehyde xanthan gum interpenetrated hydroxypropyl methylcellulose gels were developed for the controlled delivery different antibiotic drugs including ampicillin, minocyclin...