Chitosan-coated magnetic nanoparticles (CMNP) were obtained at 70 °C and 80 °C in a one-step method, which comprises precipitation in reverse microemulsion in the presence of low chitosan concentration in the aqueous phase. X-ray diffractometry showed that CMNP obtained at both temperatures contain a mixture of magnetite and maghemite nanoparticles with ≈4.5 nm in average diameter, determined b...

Nanotechnology is gaining tremendous impetus in the present century due to its capability of modulating metals into their nano size, which drastically changes the chemical, physical and optical properties of metals. The extremely small size of nanoparticles help them to occupy a greater surface area and hence a better accessibility and targeted action. Nanoparticles can overcome existing drug r...

Gene therapy using polymers such as chitosan shows good biocompatibility, but low transfection efficiency. The mechanism of folic acid (FA) uptake by cells to promote targeting and internalization could improve transfection rates. The objective of this study was to synthesize and characterize FA-chitosan-DNA nanoparticles and evaluate their cytotoxicity in vitro. Chitosan-DNA and FA-Chitosan-DN...

As a biomaterial, chitosan has been widely used in tissue engineering, wound healing, drug delivery, and other biomedical applications. It can be formulated in a variety of forms, such as powder, film, sphere, gel, and fiber. These features make chitosan an almost ideal biomaterial in cell culture applications, and cell cultures arguably constitute the most practical way to evaluate biocompatib...

The aim of this study was to investigate the effect of acrylate modification on the mucoadhesion of chitosan at the nanoscale. Nanoparticles were fabricated from acrylated chitosan (ACS) via ionic gelation with tripolyphosphate and were characterized in terms of size, zeta potential, stability, and nanoparticle yield. Chitosan (CS) nanoparticles, serving as a control, were fabricated using the ...

The use of indwelling medical devices (e.g. pacemakers, prosthetic joints, catheters, etc) continues to increase, yet these devices are all too often complicated by infections with biofilm-forming microbes with increased resistance to antimicrobial agents and host defense mechanisms. We investigated the ability of chitosan, a polymer isolated from crustacean exoskeletons, to damage biofilms for...

Respiratory Syncytial Virus (RSV) is one of the most common causes of severe respiratory tract infections worldwide. An effective RSV vaccine requires the induction of mucosal immunity which is a major hurdle. Development of polymeric nanoparticle delivery systems is one of the strategies to overcome this hurdle. PLGA, a biodegradable copolymer is FDA approved and chitosan, a mucoadhesive polym...

The development of a vaccine would be essential for the control of schistosomiasis, which is recognized as the most important human helminth infection in terms of morbidity and mortality. A new approach of oral vaccination with DNA-chitosan nanoparticles appears interesting because of their great stability and the ease of target accessibility, besides chitosan immunostimulatory properties. Here...

objective(s): chitosan nanoparticles (cnps) were prepared based on the ionic gelation of chitoan with anionic compounds of ocimum basilicum leaf extract. materials and methods: after addition of ocimum basilicum leaf extract to chitosan solution, the physicochemical properties of the nanoparticles were determined by field emission scanning electron microscope (fesem), fourier transform infrared...

The crystallization of calcium carbonate (CaCO3) was investigated using a mineralization system composed of a chitosan membrane and regenerated silk fibroin (RSF). Such a system may resemble the mineralization in molluscs, where chitosan is a derivative of chitin and RSF an analogue of nacreous protein. It was found that the vaterite disks generally formed on the chitosan membrane while the ara...