The role of Chlamydia pneumoniae in asthma has drawn much attention in recent years. In this study we assessed the prevalence of C. pneumoniae infections in patients with chronic stable and acute exacerbation of asthma and compared it with normal population. Twenty adult patients with chronic stable asthma and 21 patients with acute exacerbations of asthma and 41 matched control subjects were s...

We isolated a Mycoplasma hominis-like mycoplasma from a stock culture of Chlamydia pneumoniae TW-183 obtained from the American Type Culture Collection and eradicated the contaminant by treating the stock suspension with a nonionic detergent, Igepal CA-630. The M. hominis-like mycoplasma neither inhibits nor enhances the infectivity of C. pneumoniae for HEp-2 cells.

Community-acquired pneumonia due to Chlamydia pneumoniae is associated with a benign clinical course. Severe, life-threatening pneumonia is rare and occurs only in immunocompromised hosts. We report a case of severe pneumonia complicated by acute hypoxemic respiratory failure due to primary infection with C. pneumoniae in a previously healthy 46-year-old woman.

Azithromycin, doxycycline, and rifampin, alone or in combination, were tested in vitro against Chlamydia pneumoniae AR-39. The combination of azithromycin plus rifampin showed the strongest activity and produced higher rates of eradication of C. pneumoniae from lung tissues than azithromycin alone in experimental mouse pneumonitis.

Cogan's syndrome is often preceded by upper respiratory tract symptoms. The only reported specific agent possibly involved in pathogenesis of the Cogan's syndrome was Chlamydia pneumoniae. Positive IgA, IgM and IgG antibodies against C. pneumoniae in our patient suggest possibility of Chlamydia's role as a trigger for the vasculitis.

no antibodies to brucella when tested 9 months later is evidence against a common source of infection. Brucellosis in domestic animals has not been recorded in Sweden since the 1950s, and human brucellosis acquired in this country has not been reported since then. The possibility of coital transmission of bmcella has long been suggested, but only recently has brucellosis been isolated from huma...

Oral azithromycin has been used successfully to treat rosacea, a chronic skin disease that requires long-term therapy. A study was undertaken to determine if C. pneumoniae could play a causative role in acne rosacea. A series of 10 adults presenting with acne rosacea were selected to receive azithromycin alone for the treatment of acne rosacea. C. pneumoniae was detected in cheek biopsy specime...

AIMS To use the polymerase chain reaction (PCR) to detect Chlamydia pneumoniae and Chlamydia psittaci in sputum samples. METHODS A nested PCR was developed, the first stage of which amplified DNA from both C pneumoniae and C psittaci while the second stage targeted specifically at C pneumoniae, allowing the two species to be differentiated. The primers were designed not to amplify sequences f...

Both C. pneumoniae and M. pneumoniae are common causes of respiratory tract infection. At present, both are still diagnosed in the laboratory retrospectively by serology. This is despite many publications which indicate that PCR, which is not retrospective, is extremely good at detecting these organisms. We thought that a single PCR test which could detect both organisms simultaneously in a...

The objective of this study was to determine the most common type of pathogen causing conjunctivitis. Out of 495 patients who referred to the Zahedan Eye Clinic from May 22, 199 1 to October 22, 1992,296 cases were diagnosed as nonbacterial conjunctivitis. From the remaining number of cases, two patients had chlamydia and six patients had Candida albicans, while the frequency of bacterial i...