OBJECTIVE To determine the prevalence of genital tract Chlamydia trachomatis infection in women and men attending different health care settings in Portsmouth and South East Hampshire. DESIGN Prospective, opportunistic screening. SETTING Multiple health care sites. PARTICIPANTS Consenting sexually active women and men. INTERVENTION A urine sample was tested for Chlamydia trachomatis and...

Chlamydia trachomatis infections, which most frequently are asymptomatic, are major public health concerns globally. The 2015 European C. trachomatis guideline provides: up-to-date guidance regarding broader indications for testing and treatment of C. trachomatis infections; a clearer recommendation of using exclusively-validated nucleic acid amplification tests for diagnosis; advice on (repeat...

Chlamydia trachomatis is a leading cause of sexually transmitted infection worldwide and responsible for myriad of immunopathological changes associated with reproductive health. Delayed secretion of proinflammatory chemokine interleukin (IL)-8 is a hallmark of chlamydial infection and is dependent on chlamydial growth. We examined the effect of iron chelators on IL-8 production in HeLa 229 (ce...

Background Chlamydia trachomatis is the most common bacterial sexually transmitted infection worldwide. It is the commonest cause of non-gonococcal urethritis in men and can cause serious complications in the female reproductive tract if left untreated. Objective The aim of this study is to establish the prevalence of Chlamydia trachomatis infection in symptomatic patients attending the

Chlamydia trachomatis (CT) infection is a common cause of tubal factor infertility, and is considered a contraindication for tubal surgery. In vitro fertilization with embryo transfer (IVF/ET) is the most widely used treatment for tubal factor infertility, including that caused by CT infection. Falloposcopy to re-canalize occluded tubes may also be useful therapeutically. It is unclear, however...

OBJECTIVE To investigate epidemiologic tubal infertility risk factors and the relationship between HLA class II alleles and Chlamydia trachomatis tubal infertility. METHODS Forty-seven women with tubal infertility and 46 fertile controls were studied in Nairobi, Kenya. A questionnaire was administered and serum collected for measurement of C trachomatis antibodies. HLA class II molecular typi...

In an analytical-method comparison study of clinical samples, the Abbott RealTime CT new formulation assay (m2000 real-time PCR), consisting of a duplex PCR targeting different parts of the cryptic plasmid in Chlamydia trachomatis, was compared both with version 2 of the Roche Cobas TaqMan CT assay, comprising a duplex PCR for a target in the cryptic plasmid and the omp1 gene, and with the Gen-...

mediciNe & HeAltH/RHode islANd Chlamydia traChomatis (Ct) And Neisseria gonorrhoeae (NG) are the two most common reportable sexually transmitted infections (STIs) in the United States. Adolescent girls (15 to19 years of age) and young women (20 to 24 years of age) are at highest risk for these infections. This likely reflects a combination of factors, including biological differences that place...

BACKGROUND Anal lymphogranuloma venereum (LGV) infections, caused by Chlamydia trachomatis biovar L (Ct+/LGV+), are endemic among men who have sex with men (MSM). Anal non-LGV biovar Ct infections (Ct+/LGV-) can be eradicated with 1 week doxycycline, whereas Ct+/LGV+ infections require 3-week doxycycline. To differentiate Ct+/LGV+ from Ct+/LGV- infections, biovar-specific Nucleic Acid Amplifica...