OBJECTIVE To focus on the asthmatic pathogenesis and clinical manifestations related to epithelial sodium channel (ENaC)/chlorine ion channel. DATA SOURCES The data analyzed in this review were the English articles from 1980 to 2015 from journal databases, primarily PubMed and Google Scholar. The terms used in the literature search were: (1) ENaCs; cystic fibrosis (CF) transmembrane conductan...

Manocha and colleagues [1] found in a retrospective study on the association of beta-agonist use and lung injury a shorter duration and less severity of lung injury in patients on aerosolized beta-agonists. In their discussion of possible causes they and the investigators of the beta-agonist lung injury trial [2] did not comment on the effect of beta-agonist treatment on pulmonary chloride tran...

Patches of freshly isolated epithelial cells from eel Anguilla anguilla intestine bathed by the same solution on both sides in the cell-attached configuration had conductances of 57.0+/-1.8 pS (for positive voltages) and 13.3+/-0.7 pS (for negative voltages) (means +/- s.e.m., N=25). Electrical activity was spontaneous in the cell-attached configuration, but was frequently lost after excision. ...

The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 148 No. 5 367–373 https://doi.org/10.1085/jgp.201611686 367 Elucidating the oligomeric structure of ion channels is central to understanding their function (Marsh and Teichmann, 2015). The vast majority of ion channels are formed by multiple subunits organized as an annulus surrounding a solitary, centrally located ion-conductin...

The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 148 No. 5 367–373 https://doi.org/10.1085/jgp.201611686 367 Elucidating the oligomeric structure of ion channels is central to understanding their function (Marsh and Teichmann, 2015). The vast majority of ion channels are formed by multiple subunits organized as an annulus surrounding a solitary, centrally located ion-conductin...

The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 148 No. 5 367–373 https://doi.org/10.1085/jgp.201611686 367 Elucidating the oligomeric structure of ion channels is central to understanding their function (Marsh and Teichmann, 2015). The vast majority of ion channels are formed by multiple subunits organized as an annulus surrounding a solitary, centrally located ion-conductin...

Fluid and electrolyte transport is driven by transepithelial Cl- movement. The opening of Cl- channels in the apical membrane of salivary gland acinar cells initiates the fluid secretion process, whereas the activation of Cl- channels in both the apical and the basolateral membranes of ductal cells is thought to be necessary for NaCl re-absorption. Saliva formation can be evoked by sympathetic ...

Many olfactory receptor neurons use a cAMP-dependent transduction mechanism to transduce odorants into depolarizations. This signaling cascade is characterized by a sequence of two currents: a cation current through cyclic nucleotide-gated channels followed by a chloride current through calcium-activated chloride channels. To date, it is not possible to interfere with these generator channels u...

Propofol is multiple influences on organism function that could affect gene expressions of ion channels, cause arhythmia, impair brain cognitive functions, inhibit energy metabolism and increase hypoxic tolerance. To evaluate whether these phenomena might still exist in persistent low concentration of propofol exposure. We investigated changes in the mRNA levels of Daphnia 120 ion channel genes...

Chloride is the principal anion in the extracellular fluid and is the second main contributor to plasma tonicity. Its concentration is frequently abnormal in intensive care unit patients, often as a consequence of fluid therapy. Yet chloride has received less attention than any other ion in the critical care literature. New insights into its physiological roles have emerged together with progre...