OBJECTIVE The aim of this study was to investigate expressed preferences for family physician (FP) gender among Canadian European-descent (CED) and Canadian South-Asian (CSA) immigrant women. METHOD An 'on-site' survey was conducted in community-based institutions in Toronto in order to determine preferences for the gender of FP under various health care scenarios: overall health care; gender...

Coeliac disease (CeD) is a highly heritable common autoimmune disease involving chronic small intestinal inflammation in response to dietary wheat. The human leukocyte antigen (HLA) region, and 40 newer regions identified by genome wide association studies (GWAS) and dense fine mapping, account for ∼40% of the disease heritability. We hypothesized that in pedigrees with multiple individuals wit...

The purpose of this study was to investigate the regeneration effect waste cooking oil (WCO) on aged asphalt with molecular dynamics (MD) simulation, comparing it a rejuvenator. Firstly, models virgin and were established by blending four components (saturate, aromatic, resin, asphaltenes). Then, different dosages rejuvenator WCO (6, 9, 12%) included in model for its regeneration. After that, M...

This paper examines the root causes of Knowledge Management (KM) project abandonment. The authors use root cause analysis to identify the causes of KM project abandonment in five well-documented cases of KM drawn from the literature. The findings are synthesized into a Cause-Effect Diagram (CED), culminating in a causal model of KM project abandonment. The model identifies three major categorie...

Activation of the type I insulin-like growth factor receptor (IGF-IR) blocks osmotic mediated programmed cell death (PCD) in neurons. We speculated that IGF-IR activation could afford neuroprotection either by effecting the negative regulators of the death pathway, Bcl-2 and Bcl-xL, or by altering activity of the ced-3/ICE-like proteases. Here we report that osmotic stress decreases total neuro...

Programmed cell death (PCD) in mammals has been implicated in several disease states including cancer, autoimmune disease, and neurodegenerative disease. In Caenorhabditis elegans, PCD is a normal component of development. We find that Salmonella typhimurium colonization of the C. elegans intestine leads to an increased level of cell death in the worm gonad. S. typhimurium-mediated germ-line ce...

To the Editor : Cranioectodermal dysplasia (CED, Sensenbrenner syndrome, OMIM 218330) is a rare autosomal recessive ciliopathy characterized by craniosynostosis, dolichocephaly, narrow chest, sparse hair, epicanthal folds, microdontia, brachydactyly, joint laxity, ophthalmological problems (nystagmus, myopia, and retinal dystrophy), nephronophthisis and cystic liver disease. CED is a geneticall...

Molecular dynamics (MD) simulations of chloroform vapor and liquid at normal temperature and pressure and liquid under hydrostatic pressure are presented, giving bond lengths and vibrational frequencies as functions of pressure. The change in bond lengths between vapor and liquid at normal temperature and pressure is consistent with a pressure equivalent to the cohesive energy density (CED) of ...

OBJECTIVE To quantify the cumulative effective dose (cED) of radiation due to repeated CT and PET/CT examinations after curative resection of gastric cancer and to assess the lifetime attributable risk (LAR) estimates based on Biological Effects of Ionizing Radiation VII models. SUBJECTS AND METHODS Patients who underwent a curative resection for gastric cancer between January 2006 and Decemb...