The deregulation of the immune response is a critical component in inflammatory disease. Recent in vitro data show that T-cell protein tyrosine phosphatase (TC-PTP) is a negative regulator of cytokine signaling. Furthermore, tc-ptp(-/-) mice display immune defects and die within 5 weeks of birth. We report here that tc-ptp(-/-) mice develop progressive systemic inflammatory disease as shown by ...

Presentation of Case Dr. John H. Stone: A 26-year-old woman was seen in the rheumatology clinic of this hospital because of painful swelling on both sides of the neck. She had been well until approximately 3 months earlier, when dry mouth and increased thirst developed. Two weeks later, submental swelling occurred that was associated with local tenderness, pain on swallowing (with solids more t...

Sialoliths most commonly occur in the submandibular gland. We present a case of a giant sialolith in the hilum of the submandibular gland. A 58-year-old male patient was referred to our department for treatment of a fracture in the right mandible with swelling and pain; he did not complain of any complications in the left mandibular region. In a panoramic radiograph and CT examinations, a large...

This article details two case reports and reviews the extant literature concerning acute postoperative submandibular sialadenitis occurring in the side contralateral to the operated site after neurosurgery. Although its precise pathogenesis remains to be elucidated, it is likely related to intraoperative compression of the submandibular gland and surrounding tissues, caused by head positioning ...