Ciliary neurotrophic factor was discovered based on its ability to support the survival of ciliary neurons, and is now known to act on a variety of neuronal and glial populations. Two distant relatives of ciliary neurotrophic factor, leukemia inhibitory factor and oncostatin M, mimic ciliary neurotrophic factor with respect to its actions on cells of the nervous system. In contrast to ciliary n...

A reproducible technique, utilising a graphics tablet and a personal computer for measuring ciliary orientation from electron micrographs of ciliated epithelium, was assessed. Ciliary deviation was measured in 47 normal subjects (mean ciliary deviation ± 1 SD was 14-6 (3.30)), in eight patients with bronchiectasis and normal ciliary function (15.1 (6 50)), and in seven patients with primary cil...

A reproducible technique, utilising a graphics tablet and a personal computer for measuring ciliary orientation from electron micrographs of ciliated epithelium, was assessed. Ciliary deviation was measured in 47 normal subjects (mean ciliary deviation +/- 1 SD was 14.6 (3.3 degrees)), in eight patients with bronchiectasis and normal ciliary function (15.1 (6.5 degrees], and in seven patients w...

Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking. Using a photoconvertible fluorescent protein tag, we establish an assay that allows a separate but simultaneous examination of ciliary entry and exit of the Hedgehog signaling protein Smoothened in individual cells. ...

Uveal melanoma (UM) is the most frequent intraocular malignancy in adults, affecting iris, choroid, and ciliary bodies [...]

In the current study, behavior of crank-slider mechanism with single and multiple clearance joints are analyzed. Using Lankarani-Nikravesh theory for estimating discontinuous contact forces in clearance joints, relevant systems have been mathematically modeled. Through numerical simulations, perturbations in response of mechanisms with clearance joints have been analyzed. Effects of increasing ...

Trace metals are available to marine bivalves through uptake from both the aqueous and dietary phases. In this study, I sought to determine if there is any interaction between these 2 exposure pathways. The uptake of Cd and Se by green mussels Perna viridis from the aqueous phase was measured at different phytoplankton concentrations (green alga Chlorella autotrophica). Controlled experiments w...

Thyme is a herb with broncholytic und secretomotoric effects. Its activity on beta (2) receptors as a possible mechanism of action was demonstrated. Major components are thymol and carvacrol which are claimed to be responsible for its effects and, therefore, used for standardization in the German pharmacopoeia (0.03 % phenols calculated as thymol). Our aim was to investigate the impact of thymo...

1995;107;747-751 Chest Joseph H. Sisson, Anthony J. Yonkers and Robert H. Waldman Frequency in Healthy Volunteers Mucociliary Clearance and Ciliary Beat Effects of Guaifenesin on Nasal http://chestjournal.org/cgi/content/abstract/107/3/747 Wide Web at: information and services can be found online on the World The online version of this article, along with updated 0012-3692. ). ISSN: http://www....

The elderly are at much higher risk for developing pneumonia than younger individuals. Pneumonia is a leading cause of death and is the third most common reason for hospitalization in the elderly. One reason that elderly people may be more susceptible to pneumonia is a breakdown in the lung's first line of defense, mucociliary clearance. Cilia beat in a coordinated manner to propel out invading...