In this demo, conference attendees will try out a new system for providing multi-sensory transit and way-finding information about New York City subways to riders who are blind, visually impaired, or otherwise print disabled. The system includes a booklet of raised-line and textured maps of train routes; users explore the maps through various combinations of vision and tactile sense, and then t...

Despite significant advances in the understanding of lung cancer biology, the prognosis of cancer patients remains poor. Part of the failure of anticancer therapy is due to intratumoral heterogeneity in these patients that limits the efficacy of single agents. Therefore, there is an urgent need for new anticancer drugs or drug combination regimens that possess increased activity against all cel...

BACKGROUND AND OBJECTIVE Glucosamine is a safe and common treatment for osteoarthritis. Even so, literature data on the cardiovascular safety of glucosamine are limited. The objective of this paper is to investigate the long-term effects of crystalline glucosamine sulfate (CGS) on key measures of cardiovascular risk in patients with osteoarthritis. METHODS We analyzed safety data from two lon...

Understanding groundwater geochemistry is crucial for water supply in arid regions. The present research was conducted the Mo river watershed on Tibetan plateau to gain insights into geochemical characteristics, governing processes and quality of endorheic watersheds. A total 28 samples were collected from phreatic confined aquifers hydrochemical analysis. results showed that slightly alkaline ...

We assume that m facility units (hospital, bank, post office, fire department, police station, bus station, etc.) are requested to be established for n cities which are on the same line. We have to choose m cities where the facility units will be established such that total distance from all cities to nearest facility units is minimum. Here, it is supposed that the person who is in the city whi...

Agonists of adenosine A2A receptors (A2ARs) suppress the activation of most immune cells and reduce acute inflammatory responses. Asthma is characterized by sensitization in response to initial allergen exposure and by airway hyperreactivity in response to allergen rechallenge. We sought to determine if A2AR activation with CGS-21680 (CGS) is more effective when CGS is administered during sensi...

In vivo microdialysis in C57BL/6J (B6) mouse was used to test the hypothesis that activating adenosine A(2A) receptors in the pontine reticular formation (PRF) increases acetylcholine (ACh) release and rapid eye movement (REM) sleep. Eight concentrations of the adenosine A(2A) receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine hydrochloride (CGS 21680; CGS) were ...

Cardiac glycosides (CGs), inhibitors of Na+/K+-ATPase (NKA), used clinically to treat heart failure, have garnered recent attention as potential anti-cancer and anti-viral agents. A high-throughput phenotypic screen designed to identify modulators of promyelocytic leukemia protein (PML) nuclear body (NB) formation revealed the CG gitoxigenin as a potent activator of PML. We demonstrate that mul...