PURPOSE A percentage of trabecular meshwork (TM) cells in tissue and organ culture have been shown to contain cross-linked actin networks (CLANs) when exposed to dexamethasone, as have TM cultures derived from glaucomatous individuals. The purpose of this study was to determine whether CLANs exist within TM cells in situ in tissue unmanipulated by culturing, thereby eliminating the possibility ...

The Nudix homology clan encompasses over 80,000 protein domains from all three domains of life, defined by homology to each other. Proteins with a domain from this clan fall into four general functional classes: pyrophosphohydrolases, isopentenyl diphosphate isomerases (IDIs), adenine/guanine mismatch-specific adenine glycosylases (A/G-specific adenine glycosylases), and nonenzymatic activities...

Introduction The accurate division of the gait cycle into its component stance and swing phases is important in gait analysis. Use of force platforms to indicate when the foot is in contact with the ground is the 'gold standard' method of determining foot strike (FS) and toe off (TO). However force platforms may not be available, particularly during treadmill locomotion. Methods of determining ...

The Ankle Mimicking Prosthetic Foot 3 is an energy efficient bionic foot using the principle of optimal power distribution. The main challenge behind this research is focussed on retrieving as much energy as possible from the gait and to incorporate an electric actuator with minimized power consumption. The Ankle Mimicking Prosthetic (AMP-) Foot 2, as a proof-of-concept, showed the advantage of...