Khon Konchog Gyalpo, the main disciple of Drogmi, founded a monastery at Sakya. It was this that gave its name to whole monastic order Drogmi. member clan, family went on produce successive abbots or chief lamas Sakya who have continued as heads ever since. The succession within established father-to-son uncle-to-nephew pattern. In instance an abbot remaining celibate, it his brother close rela...

Virtual Interface Architecture(VIA) is a light-weight protocol for protected user-level zero-copy communication. In spite of high performance of VIA, the previous MPI implementation for GigaNet’s cLAN revealed low communication performance. The main sources of the low performance are the discrepancy of communication model between MPI and VIA and multi-threading overhead. In this paper, we propo...

The exopeptidases of family S46 are exceptional, as the closest homologs of these enzymes are the endopeptidases of clan PA. The three-dimensional structure of S46 enzymes is unknown and only one of the catalytic residues, the serine, has been identified. The catalytic histidine and aspartate residues are not experimentally identified. Here we present phylogenetic and experimental data that ide...

n engl j med 371;7 nejm.org august 14, 2014 596 penetrant genetic mutations that predictably result in disease, clinical sequencing will enable individual screening, monitoring, prevention, and treatment of medically actionable conditions. On the other hand, there will be a large proportion of potentially deleterious variants associated with medium-sized odds ratios for disease and variable phe...

The difference between failure and success in developing a software-intensive system can often be traced to the presence or absence of clashes among the models used to define the system’s product, process, property, and success characteristics. (Here, we use a simplified version of one of Webster’s definitions of “model” a description or analogy used to help visualize something. We include anal...

No universal strategy exists for humanizing mouse antibodies, and most approaches are based on primary sequence alignment and grafting. Although this strategy theoretically decreases the immunogenicity of mouse antibodies, it neither addresses conformational changes nor steric clashes that arise due to grafting of human germline frameworks to accommodate mouse CDR regions. To address these issu...

Previous rotamer libraries showed little significant clustering for asparagine chi2 or glutamine chi3 values, but none of those studies corrected amide orientations or omitted disordered side chains. The current survey used 240 proteins at /=0.4 A). All H atoms were added and optimized, and amide orientat...

BACKGROUND Although childhood hyperactivity is a common, serious, and treatable disorder, most affected children in Britain do not receive effective treatment. AIM To investigate the views that parents and GPs hold about hyperactivity, and to explore how far these views, and clashes between these views, influence access to services. METHOD Qualitative study making use of semi-structured int...

Introduction When studying the function of the human foot, foot pressure measurements offer some insight into the biomechanics of the growing foot [1] and models have been proposed to measure the foot kinematics especially of children [2]. Aside from ankle kinematics however [3], little is known about differences in foot motion between children and adults. This ongoing study therefore examines ...