BACKGROUND Despite bronchiectasis being increasingly recognised as an important cause of chronic respiratory morbidity in both indigenous and non-indigenous settings globally, high quality evidence to inform management is scarce. It is assumed that antibiotics are efficacious for all bronchiectasis exacerbations, but not all practitioners agree. Inadequately treated exacerbations may risk lung ...

Bacteria and their products stimulate inflammatory responses. The effects of different antimicrobial regimens (amoxicillin/clavulanic acid, tobramycin, imipenem, vancomycin, metronidazole) were investigated on the course of experimental colitis induced by trinitrobenzenesulphonic acid (TNB) in the rat. On day 7 and 21 after the induction of colitis, matched groups of control and antibiotic trea...

Streptomyces clavuligerus produces at least five different clavam metabolites, including clavulanic acid and the methionine antimetabolite, alanylclavam. In vitro transposon mutagenesis was used to analyze a 13-kb region upstream of the known paralogue gene cluster. The paralogue cluster includes one group of clavulanic acid biosynthetic genes in S. clavuligerus. Twelve open reading frames (ORF...

Background. The objective of this study was to identify the bacteria most frequently responsible for urinary tract infection (UTI) in the population of under-2-year-olds in our geographic area and to evaluate the activity of antibiotics widely used for UTI treatment during a 4-year study period. Materials and Methods. A retrospective analysis was conducted of data on the identification and susc...

Clavulanic acid (CA) is a potent inhibitor of β-lactamases, enzymes that are responsible for the hydrolysis of β-lactam antibiotics. It is a secondary metabolite produced by the filamentous aerobic bacterium Streptomyces clavuligerus in submerged cultivations. In the present work clavulanic acid production in batch, fed-batch and continuous bioreactors was studied with the objective of increasi...

A simple, rapid, specific and sensitive liquid chromatography tandem mass spectrometric method has been developed and validated for the simultaneous determination of Amoxicillin and Clavulanic acid from 250μL of human plasma by Solid Phase Extraction. Hydrochlorothiazide was used as an internal standard. Quantified by the transition, 364.060→223.160, 198.061→136.000 for Amoxicillin and Clavulan...

introduction: escherichia coli (e.coli) as a main cause of both nosocomial and community-acquired infections in humans have a relative potential to develop resistance. nowadays, most infections caused by esbl-producing e.coli (esblec) had mostly been described as nosocomial acquired or nursing home related. in this study, we employed e-test assay to detect antibiotic resistance of e.coli strain...

OBJECTIVE To describe the epidemiology, the surgical treatment, the microbiology, the antibiotic prophylaxis and the outcome of patients with the most severe type of open fractures. METHODS Retrospective chart reviews of patients with Gustilo type III open fracture admitted to an university hospital in Switzerland between January 2007 and December 2011. The patient's and fracture's characteri...