Abstract Cleft births surveillance is essential in healthcare and prevention planning. Data are needed precision medicine to target upstream management for at-risk individuals. This study characterizes Singapore’s population-based orofacial cleft topography by ethnicity gender, establishes the cohort’s infant mortality rate. Data, decade 2003 2012, were extracted National Birth Defects Registry...

BACKGROUND In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and orofacial clefts in India have reported inconsistent results. Therefore, we conducted a systematic revi...

Introduction Osteoporotic vertebral compression fractures (VCF) are common in routine medical practice and usually heal without neurologic complications. However, vertebral bodies that are severely osteoporotic and located in thoracolumbar junction are more susceptible to non-healing with resultant intravertebral cleft formation (1). Recently, dynamic contrast enhanced magnetic resonance imagin...

The results of previous epidemiologic research on the possible association between maternal smoking during pregnancy and risk of oral clefts in offspring have been inconsistent. This may be due in part to methodological limitations, including imprecise measurement of tobacco use, failure to consider etiologic heterogeneity among types of oral clefts, and confounding. This analysis, based on a l...

Electron microscopy has revealed an abundance of material in the clefts of synapses in the mammalian brain, and the biochemical and functional characteristics of proteins occupying synaptic clefts are well documented. However, the detailed spatial organization of the proteins in the synaptic clefts remains unclear. Electron microscope tomography provides a way to delineate and map the proteins ...