We have previously shown that a 2-chloro-1,4-naphthoquinone derivative (TW-92) induces cell death in leukemia cells. TW-92 exhibited relatively high selectivity towards primary Acute Myeloid Leukemia (AML) cells, as compared to normal mononuclear cells. In view of the selectivity of this family of naphthoquinones, novel chloroaminophenylnaphthoquinone isomers with different methyl substitutions...

Atrazine, a pre-emergent herbicide in the chloro-s-triazine family, has been widely used in crop lands and often detected in agriculture watersheds, which is considered as a potential threat to human health. Although atrazine and its metabolites showed an elevated incidence of mammary tumors in female Sprague-Dawley (SD) rats, no molecular evidence was found relevant to its carcinogenesis in hu...

The turnip (Brassica rapa L.) microsome fraction contains both a Mg(2+)-inhibited acid phosphatase and a salt-stimulated Mg(2+)-activated ATPase. However, as the pH optimum of the ATPase was 8.0 to 8.5, the acid phosphatase activity could be eliminated by assaying at or above pH 7.8. The ATPase was concentrated in a fraction equivalent to the smooth microsomal membranes and was not due to fragm...

-To eliminate mercury vapor from gas streams, three major methods are used: condensation, absorption, and adsorption. This work deals with adsorption, using elemental sulfur as an active phase supported on sepiolite and palygorskite fibrous clays. Sulfur loads of 5-30% were deposited by catalytic oxidation of hydrogen sulfide at temperatures of < 200~ the clays acting first as a catalyst of the...

Background—Fascioliasis is a parasitic infection, primarily of the liver but after several weeks the biliary tract may also be aVected, related to the trematode Fasciola hepatica. The trematode is distributed worldwide in herbivores but is unusual in humans. Several outbreaks have been attributed to consumption of contaminated watercress and water. The optimal treatment of fascioliasis, particu...

Aims: To evaluate the potential role of serum cystatin C as a marker of renal function in patients with ovarian cancer. Methods: Treatment of consecutive ovarian cancer patients who were eligible for chemotherapy with paclitaxel (135 mg/ m 2 /24 h) and cisplatin (75 mg/m 2 ) every 3 weeks in 6 cycles. Glomerular filtration rate (GFR) markers, i.e. serum levels of creatinine and cystatin C, esti...

a n a ly t ica l in fo rm ation Figure 1. Overview of the different modules of the system. —domain independency —semiautomatic: the user is consulted if the system encounters problems. The last starting point is based on the aforementioned publications concerning automatic information extracting which reveal that information extraction based on Natural Language techniques is still very difficul...

Aims: To evaluate the potential role of serum cystatin C as a marker of renal function in patients with ovarian cancer. Methods: Treatment of consecutive ovarian cancer patients who were eligible for chemotherapy with paclitaxel (135 mg/ m 2 /24 h) and cisplatin (75 mg/m 2 ) every 3 weeks in 6 cycles. Glomerular filtration rate (GFR) markers, i.e. serum levels of creatinine and cystatin C, esti...

Baltasar-George Sage (1740-1824), a conflictive chemist and mining engineer, and one of the last supporters of the phlogiston theory and the old chemical nomenclature, carried on a large number of metallurgical researches, discovered hypophosphoric acid and solid potassium ferrocyanide. His most achievement was the foundation of the School of Mines of Paris. LIFE AND CAREER In his biography Bal...