Parkinson's disease (PD), a neurodegenerative disorder, is accompanied by various non-motor symptoms including depression and anxiety, which may precede the onset of motor symptoms. Selegiline is an irreversible monoamine oxidase-B (MAO-B) inhibitor, and is widely used in the treatment of PD and major depression. However, there are few reports about the effects of selegiline on non-motor sympto...

Synapse elimination is considered to be the final step in neural circuit formation, by causing refinement of redundant connections formed at earlier developmental stages. The developmental loss of climbing fiber innervation from cerebellar Purkinje cells is an example of such synapse elimination. It has been suggested that NMDA receptors are involved in the elimination of climbing fiber synapse...

JEFFREY M. JANOT, JEFF P. STEFFEN, JOHN P. PORCARI, AND MARGARET A. MAHER. Heart rate responses and perceived exertion for beginner and recreational sport climbers during indoor climbing. JEPONLINE 3(1):17, 2000. The purpose of this investigation was to compare heart rate (HR) and ratings of perceived exertion (RPE) of beginner and recreational sport climbers during indoor climbing. Seventeen b...

no unique method has been so far specified for determining the number of neurons in hidden layers of multi-layer perceptron (mlp) neural networks used for prediction. the present research is intended to optimize the number of neurons using two meta-heuristic procedures namely genetic and hill climbing algorithms. the data used in the present research for prediction are consumption data of water...

This paper proposes a novel application of the Stewart–Gough parallel platform as a climbing robot and its kinematics control to climb through long structures describing unknown spatial trajectories, such as palm trunks, tubes, etc. First, the description and design of the climbing parallel robot is presented. Second, the inverse and forward kinematics analysis of a mobile six-degrees-of-freedo...