Journal of Family Planning and Reproductive Health Care 2003: 29(2) Clinical scenario A busy family planning clinic (FPC) finally draws to a close, during which you demonstrated the insertion of several intrauterine devices (IUDs) to a general practitioner (GP) registrar and also supervised him inserting an IUD for the first time. Over coffee at the end of the session he tells you that his GP t...

A key objective in the clinical development of a medicinal drug is the determination of an adequate dose level and, more broadly, the characterization of its dose response relationship. If the dose is set too high, safety and tolerability problems are likely to result, while selecting too low a dose makes it difficult to establish adequate efficacy in the confirmatory phase, possibly leading to...

This is an interesting case series on a very common genetic condition which are often diagnosed late as clinical signs are inconspicuous. We would like to highlight the principal clinical examination finding which led to diagnosis.

The traditional statistical analysis of data from clinical trials tends to follow a conservative approach centred around pre-specification, hypothesis testing and regulatory considerations. On the other hand, attempts to take a more exploratory approach are often criticised for being open-ended ‘data dredging’ exercises, lacking prespecification, and failing to adequately control type I error. ...

Turner syndrome (TS) is the most common sex chromosome abnormality of female, occurs in one in 2500 live-born females. TS combines’ characteristic physical features with complete or partial absence of the X chromosomes, frequently accompanied by cell mosaicsm. The aims of this study is to describe the clinical phenotype and karyotype of patient with Turner Syndrome in Jakarta, Indonesia. Data w...

The patient with word-finding difficulty presents a common and challenging clinical problem. The complaint of 'word-finding difficulty' covers a wide range of clinical phenomena and may signify any of a number of distinct pathophysiological processes. Although it occurs in a variety of clinical contexts, word-finding difficulty generally presents a diagnostic conundrum when it occurs as a leadi...

Ganglioneuroma is a benign neoplasm derived from the neural crest consisting of mature ganglionic cells and Schwann cells. The posterior mediastinum is its most common location, followed by the retroperitoneum. Only a small proportion of ganglioneuromas arise from the adrenal medulla (15--30%). The routine use of imaging tests has increased the frequency of diagnosis of adrenal incidentalomas. ...