The article presents an outline of the requirements concerning the planning of preclinical and clinical studies, necessary for the legal approval of a medicinal product. It describes the clinical research plan of innovative and generic pharmaceutical products, taking into account the specific situations in which the assessment of biological equivalence of a generic product is not possible based...

We argue that in the high energy QCD a true black disk wave function consists not only of many gluons but also from many quarks. This corresponds to necessity of nonvacuum reggeon loops in formation of a black disk. The result comes from decomposition of the black disk S-matrix in characters on group manifold. Usually black disk defined as some dense state, which absorbs any projectile. In this...

the aim of the present studyis radiographic evaluation of urinary system and the effect of urografin on clinical parameters, urinalysis and renal function tests in sheep. six clinically healthy female sheep were selected for this study.before experiment, vital signs were recorded. blood and urine samples were collected prior to the trials and paraclinical examinations were performed. urine samp...