BACKGROUND A standardized systematic approach to grade evidence and the strength of recommendations is important for guideline users to minimize bias and help interpret the most suitable decisions at the point of care. The study aims to identify and classify determinants used to make judgement for the strength of recommendations among 56 Korean clinical practice guidelines (CPGs), and explore s...

BACKGROUND In more and more countries, a specific pain education curriculum is provided to instruct pain physicians. However, there is little literature on pain education and in particularly how to evaluate their knowledge. One of the modules interesting to assess is the use of clinical practice guidelines (CPGs) by pain physicians. OBJECTIVES The aim was to investigate if a case vignette is ...

INTRODUCTION Evidence indicates a need to recruit more GPs to a career in rural general practice (GP). Research has indicated that placement experiences have the potential to impact on medical career decision-making. Research also suggests that rural placements can raise both professional and psychosocial concerns, but there is no existing evidence about whether pre-placement expectations trans...

Quality and ethics need to be embedded into all areas of research with human participants. Good Clinical Practice (GCP) guidelines are international ethical and scientific quality standards for designing, conducting, recording and reporting trials involving human participants. Compliance with GCP is expected to provide public assurance that the rights, safety and wellbeing of participants are p...

Department of Nephrology, University of Queensland at the Princess Alexandra Hospital, Child & Adolescent Renal Service, Royal Children’s and Mater Children’s Hospitals, Brisbane, Queensland, Renal Transplant Unit, Royal Prince Alfred Hospital, Sydney, New South Wales, Department of Nephrology, Monash Medical Centre and Department of Medicine, Monash University, Melbourne, Victoria, and Renal T...

Good Clinical Practice (GCP) is an international standard for the design, conduct, performance, monitoring, auditing, recording, analyses, and reporting of clinical trials. The goal of GCP is to ensure the protection of the rights, integrity, and confidentiality of clinical trial participants and to ensure the credibility and accuracy of data and reported results. In the United States, trial sp...

BACKGROUND While the potential of clinical practice guidelines (CPGs) to support implementation of evidence has been demonstrated, it is not currently being achieved. CPGs are both poorly developed and ineffectively implemented. To improve clinical practice and health outcomes, both well-developed CPGs and effective methods of CPG implementation are needed. We sought to establish whether there ...

Veterinary clinical trials generate data that advance the transfer of knowledge from clinical research to clinical practice in human and veterinary settings. The translational success of non-regulated and regulated veterinary clinical studies is dependent upon the reliability and reproducibility of the data generated. Clinician-scientists that conduct veterinary clinical studies would benefit f...

Adaptation is a central process in the life cycle of clinical practice guidelines (CPGs), if a broad acceptance is to be achieved. Currently, there is no fully integrated solution for this process available. Due to the risk of introducing errors or compromising the evidence base, users and persons in charge often hesitate. To overcome these problems, we present a manageable pathway for the adap...