Clot formation is a common complication in extracorporeal circuits. In this paper we describe a novel method for clot formation analysis using image processing. We assembled a closed extracorporeal circuit and circulated blood at varying speeds. Blood filters were placed in downstream of the flow, and clotting agents were added to the circuit. Digital images of the filter were subsequently take...

The procedure of drug approval is time-consuming, costly and risky. Accidental findings regarding multi-specificity of approved drugs led to block-busters in new indication areas. Therefore, the interest in systematically elucidating new areas of application for known drugs is rising. Furthermore, the knowledge, understanding and prediction of so-called off-target effects allow a rational appro...

1. The main site was at Dave and Busters in Columbus, Ohio. 2. We used a satellite site in the Cleveland, Ohio area at Progressive Insurance where there was a group in a conference room. We also had a few individuals attending via the web at other locations. 3. Frank Bereznay presented 2 papers from our main site. 4. Presenters Keith Tidball and Lori Zaremba from Progressive tag-teamed from 2 l...

According to four of the most popular diet books of recent years The Zone (1995), whose primary author is Barry Sears, Ph.D., Protein Power (1997), by medical doctors Michael R. Eades and Mary Dan Eades, Dr. Atkins' New Diet Revolution (1997), by Robert C. Atkins, M.D., and Sugar Busters! Cut Sugar to Trim Fat (1998), by H. Leighton Steward and associates diets high in carbohydrate (CHO) are re...

Thromboelastography (TEG) aids in monitoring a patient's global hemostatic system by measuring the rate of clot formation, clot strength, and stability. The usefulness of TEG in pediatric settings, especially with neonates, is limited owing to a lack of neonatal reference values. In this study, neonatal TEG reference intervals were developed and results correlated with other coagulation test pa...

BACKGROUND AND PURPOSE Fibrin clot formation is important in acute intracerebral hemorrhage (ICH). We investigated plasma fibrin clot characteristics in acute ICH compared with acute ischemic stroke (IS) and nonstroke conditions. METHODS In the 3 studied groups, we analyzed plasma fibrin clot phenotype and its association with clinical stroke presentation. RESULTS Compared with controls, in...

INTRODUCTION The severity of acute pulmonary embolism can be assessed with computed tomography (CT) using clot burden estimation. We compared the existing CT obstruction scores with an in-house developed central clot score for the prediction of 30-day pulmonary embolism (PE)-related mortality. MATERIALS AND METHODS In 125 consecutive patients [47 men, 78 women; mean age +/- standard deviation...

AIM To examine effects of computed tomography (CT) image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes. METHODS This study was performed in conformance with HIPAA and IRB Regulations (March 2015-November 2016). A ten blood clot phantom was designed and scanned on a dual-energy CT scanner (SOMATOM Force, Siemens Healthcare ...

Background Easier to perform than the conventional procedure, mini-tracheostomy (MT) is widely used in the operating room or intensive care unit to remove sputum or other obstructions of the upper airway. This option, however, does carry the risk of various complications, including malposition, disposition, bleeding, and subcutaneous emphysema. Here, we report a case of endotracheal tube obstru...

Prourokinase (proUK) is a zymogenic plasminogen activator that at pharmacological doses is prone to nonspecific activation to urokinase. This has handicapped therapeutic exploitation of its fibrin-specific physiological properties. To attenuate this susceptibility without compromising specific activation of proUK on a fibrin clot, a Lys300-->His mutation (M5) was developed. M5 had a lower intri...