Blood clotting was examined in 24 consecutive full-term newborn infants with hypoxia and 23 normal control infants. There was evidence of a gross alteration in the clotting process in the hypoxic infants. The degree of disturbance in clotting seemed to be dependent on the severity of the hypoxia, suggesting a causal relationship. The mechanism involved seemed to be intravascular coagulation. Th...

Article history: Received on: 14/10/2015 Revised on: 04/11/2015 Accepted on: 15/11/2015 Available online: 27/12/2015 The study was undertaken to evaluate milk clotting and proteolytic activity of protein fractions of seeds of Lagenaria siceraria. Protein fractions were isolated by the method of differential solubility, and their protein contents were estimated using Bio-Rad protein assay reagen...

Background: Blood group plays a vital role in the field of transfusion medicine. The relationship between bleeding time, clotting time, and blood group is important in certain clinical conditions such as epistaxis, surgery, and thrombosis. Researchers have shown that epistaxis is more often encountered in patients having blood group O probably due to lower expression of von Willebrand factor, a...

objective(s): haemostasis prevents blood loss following vascular injury. it depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. the clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. clotting insufficiency mostly occurs due to genetically inherited coagulation fact...

The clinical usefulness of a chromogenic method for prothrombin time (PT) determination has been assessed in a wide range of clinical conditions, and it is compared with the conventional clotting method for PT. The new method appears to be as sensitive as the clotting PT to deficiencies of clotting factors of the extrinsic and common pathway, except for fibrinogen. Patients with proven liver di...

Evidence for the involvement of the sixth component of complement (C6) in normal blood coagulation is provided by the description of a coagulation abnormality in rabbits with a genetic C6 deficiency and by its correction with highly purified preparations of C6. Whole blood clotting time in glass or plastic was prolonged and prothrombin consumption was decreased in blood from the deficient anima...

The adhesion and migration of human diploid fibroblasts on plasma clots were measured. The role of plasma fibronectin was examined by depleting plasma of fibronectin before clotting. Fibronectin was not essential for cell adhesion and spreading, although rates were slightly slower on depleted clots. Rates of migration on the surface of clots were unaffected by fibronectin depletion. In contrast...

Coagulation problems in pregnancy are primarily associated with overactivity of the intrinsic clotting system. This accounts for the increased incidence of thrombo-embolism during pregnancy. Where specific obstetric complications cause clotting problems the common underlying feature is usually placental pathology as in abruptio placentae, pre-eclampsia or hydatidiform mole. Abnormal activation ...

COAGULATION DISORDERS have represented useful clotting models. During the past decade new problems have appeared. Several conditions due to structural abnormalities of clotting factors have been described. Several dysfibrinogenemias, hemophilia B and BM variants, and factor X Friuli and other factor X variants are now well-defined clotting disorders. 1-8 Recently, two abnormal factor VII defect...

In hemodialysis, the patient’s blood is flown through an extracorporeal circuit containing a hemodialyzer. This process stimulates coagulation for several reasons, most notably the blood’s contact with the artificial surfaces of the tubing and dialyzer membrane and with air in the venous bubble trap, turbulent and stagnant blood flow, shear stress and hemoconcentration during the treatment [1]....