We investigate the effect of clustering on network observability transitions. In model introduced by Yang et al. (2012), a given fraction nodes are chosen randomly, and they those neighbors considered to be observable, while other unobservable. For random clustered networks, we derive normalized sizes largest observable component (LOC) unobservable (LUC). Considering case where numbers edges tr...

Society is increasingly impacted by natural hazards which cause significant damage in economic and human terms. Many of these natural hazards are weather and climate related. Here, we show that North Atlantic atmospheric circulation regimes affect the propensity of extreme wind speeds in Europe. We also show evidence that extreme wind speeds are long-range dependent, follow a generalized Pareto...

The morphology of defects formed in collision cascades is an essential aspect the subsequent evolution microstructure. morphological composition a defect decides its stability, interaction, and migration properties. We compare morphologies primary radiation damage caused by high energy simulated using three different interatomic potentials W. An automated method to identify used. While most for...

We present a linear time algorithm for testing clustered planarity of c-connected clustered graphs and for computing a clustered planar embedding for such graphs. Our algorithm uses a decomposition of the input graph based on SPQR-trees and is the first linear time algorithm for clustered planarity testing. We define a normal form of clustered embeddings and show that a clustered graph is clust...

Selective inhibitors of nuclear export (SINE) are small molecules in development as anti-cancer agents. The first-in-class SINE, selinexor, is in clinical trials for blood and solid cancers. Selinexor forms a covalent bond with exportin-1 at cysteine-528, and blocks its ability to export cargos. Previous work has shown strong cell cycle effects and drug-induced cell death across many different ...

Evidence has emerged that repair of clustered DNA lesions may be compromised, possibly leading to the formation of double-strand breaks (DSB) and, thus, to deleterious events. The first repair event occurring at a multiply damaged site (MDS) is of major importance and will largely contribute to the hazardousness of MDS. Here, using protein extracts from wild type or hOGG1-overexpressing Chinese...

Oxidative stress induced by reactive oxygen species can result in DNA damage within cells and subsequently increase risk for carcinogenesis. This may be averted by repair of DNA damage through the base or nucleotide excision repair (BER/NER) pathways. PARP, a BER protein, is known for its role in DNA-repair. However, multiple lesions can occur within a small range of DNA, known as oxidative clu...

The effects of low-dose radiation causing DNA damage continue to be subjects of interest. Problems with existing approaches to low-dose DNA damage are that single-strand breaks (the predominant radiation-induced lesion) are very rapidly repaired and that results using current methods for measuring DNA damage can be difficult to interpret. As a novel approach, we conducted studies using plants (...

Low linear energy transfer (LET) ionizing radiation (IR) is an important form of therapy for acute leukemias administered externally or as radioimmunotherapy. IR is also a potential source of DNA damage. High LET IR produces structurally different forms of DNA damage and has emerged as potential treatment of metastatic and hematopoietic malignancies. Therefore, understanding mechanisms of resis...

Damage localization and quantification constitute different aspects of structural damage diagnosis, which are particular interest in the Structural Health Monitoring field. Therein, a classical solution is model updating, where parameters finite element possibly damaged structure optimized to match with corresponding estimated from its vibration responses. To avoid ill-posedness updating proble...