Type 2 diabetes mellitus (T2DM) and persistent cytomegalovirus (CMV) infection are postulated contributors to inflammatory processes that impact on the age-related decline in T-cell responses to influenza vaccination. Older subjects with T2DM (n = 30) and healthy aged controls (n = 40) were enrolled and received influenza vaccination in this study. Serum inflammatory markers and CMV serostatus ...

The prevalence and incidence of cytomegalovirus (CMV) infections were studied in a group of homosexual men. Of the 710 participants, 501 (70.6%) had complement fixing antibodies to CMV on entry to the study. During the follow up (maximum 23 months) 69 CMV infections were found: 50 primary infections among the 209 seronegative men (attack rate 27.3%), and 19 recurrent infections among the 501 se...

The correlates of protective immunity to disease-inducing viruses in humans remain to be elucidated. We determined the kinetics and characteristics of cytomegalovirus (CMV)-specific CD4(+) and CD8(+) T cells in the course of primary CMV infection in asymptomatic and symptomatic recipients of renal transplants. Specific CD8(+) cytotoxic T lymphocyte (CTL) and antibody responses developed regardl...

objective(s):human cytomegalovirus (cmv), a double-strand dna herpesvirus, can be transmitted via blood transfusion which is especially important for immunocompromised recipients and can cause a fatal infection. cmv seroprevalence in iran was studied on blood donors, healthy subjects, and some patients. highly variable rates were detected. the purpose of this study was to review cmv seroprevale...

Two infants were considered to have acquired cytomegalovirus (CMV) infection from blood transfusions screened for the presence of CMV antibody by a haemagglutination assay. Further samples from the same donors were tested by a latex agglutination test; six of 18 (33%) previously believed seronegative were found to be seropositive.

OBJECTIVES To examine whether cytomegalovirus (CMV) and herpes simplex virus type-1 (HSV-1) are associated with cognitive decline over a 4-year period and to assess whether C-reactive protein (CRP) modifies these relationships. DESIGN Prospective cohort study over a 4-year period. SETTING Community-dwelling elderly population. PARTICIPANTS The sample was a subset (1,204/1,789) of particip...

With improvements in management of acute rejection and allograft function over the past decades, short-term survival after solid-organ transplantation is excellent, and death with a functioning graft has become the outcome for the majority of solid-organ transplant recipients. Thus, there is a necessity to focus not only on interventions to maintain graft function, but also to address other pos...

This study describes the results of testing 92 serum samples, including 10 umbilical cord serum samples, from 38 cytomegalovirus (CMV)-infected neonates for CMV-specific immunoglobulins E (IgE) and M by antibody-capture enzyme-linked immunosorbent assays with enzyme-labeled CMV antigen. All infants excreted CMV in the urine. It was demonstrated that the CMV IgE test was more sensitive than the ...

a. Prophylactic treatment for Cytomegalovirus (CMV) is recommended in solid organ transplantation as it is associated with a significant decrease in CMV disease and infection compared with placebo or no treatment (approximately a 50% and 40% decrease in relative risk, respectively) (Level I evidence). b. The use of the antiviral agents oral valganciclovir, oral valaciclovir, and intravenous gan...

A four-year survey (2012–2015) was carried out to examine the genetic diversity of cucumber mosaic virus (CMV) isolates infecting tomato, as well presence and their satellite RNAs (satRNAs), collecting a total 226 samples throughout most important growing regions in Serbia. Besides CMV-like symptoms, collected also exhibited more severe such systemic necrosis leaves, branches stems, accompanied...