Neurotechnology has made great strides in the last 20 years. However, we still have a long way to go commercialize many of these technologies as lack unified framework study cyber-neural systems (CNS) that bring hardware, software, and neural system together. Dynamical play key role developing they capture different aspects brain provide insight into their function. Converging evidence suggests...

The presence of procoagulants and fibrin deposition have been dem onstrated in malignant tumors. Although thrombin, a key enzyme in coagulation, has other various biological functions, the significance of its presence in tumors is not known. We studied the effects of thrombin on the expression of urokinase-type plasminogen activator (uPA) which is known to play a role in tumor invasion, using a...

Our objective was to estimate the in vivo rates of thrombin and fibrin generation to better understand how coagulation is regulated. Studied were 9 males undergoing cardiopulmonary bypass (CPB). The rates of thrombin, total fibrin, and soluble fibrin generation in vivo were based on measured levels of prothrombin activation peptide F1.2, thrombin-antithrombin complex, fibrinopeptide A, and solu...

In single platelets and in suspensions of platelets, alpha-thrombin evokes dose-dependent, transient increases in cytosolic Ca2+ concentration, [Ca2+]i, which are more prolonged than the [Ca2+]i transients evoked by other platelet agonists such as the thrombin-receptor-activating hexapeptide SFLLRN, thromboxane A2 analog U46619, and ADP. As a quantity taking into account both the magnitude and ...

the aim of this review is to focus the current knowledge about mental and behavioral disorders in usher syndrome. previous studies described the presence of various mental disorders associated with usher syndrome, suggesting possible mechanisms of association between these disorders. the most common manifestations are schizophrenia-like disorder and psychotic symptoms. mood and behavioral disor...

in this paper the simulation of pathological behavior in gait locomotion of central nervous system (cns) diseases and effects of rehabilitation techniques are investigated. these simulations noticeably deepen the knowledge of researches in neurorehabilitation realm about the neuroscientific basis of cns treatment after a neural disorder. however, only a limited number of these simulations have ...

enhanced immune cell trafficking into the central nervous system (cns) and disruption of the blood brain barrier are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae). however, recent studies suggest that the coagulation and the contact-kinin system might also be involved in ms developme...

crush preparation cytology technique was used during the operative procedure for the diagnosis of 199 cns tumors. this technique is simple, easy to perform, rapid, and inexpensive. the cytomorphologic findings were excellent and helped achieve a rapid and correct diagnosis. this technique was used on the tiny, small specimens which were not suitable for frozen sectioning. the results were compa...

In 2021, the WHO revised its classification of central nervous system (CNS) tumors, which has resulted in changes to both diagnostic and treatment landscapes. At NCCN 2023 Annual Conference, this tumor board–style presentation featured 4 case studies demonstrate an evidence-based approach patients with various WHO-defined types diffuse glioma. The Guidelines have been updated reflect reclassifi...