Abstract Blood-brain barrier (BBB) permeable agents effective against recurrent, chemotherapy-resistant central nervous system (CNS) tumors are urgently needed, particularly in Glioblastoma multiforme (GBM) and atypical teratoid/rhabdoid (ATRT). These represent extremely aggressive lethal types of CNS malignancies. LP-184 is a next-generation acylfulvene class drug candidate has received FDA or...

phocytes have been identified in cancer-bearing patients, including peripheral blood (1†" 4),lymphoid tissue (5†" 7), and TILs3 (3, 8†" 10). Murine models have established that an abundant source of tumor sensitized T lymphocytes is present in LN-draining s.c. tumors (11, 12). T cells from tumor-bearing mice are largely incapable of mcdi ating tumor regression when immediately transferred...

Glioblastoma is a highly invasive and aggressive brain tumor that is very difficult to treat. The rat glioma cell line CNS-1 is a widely used, well-characterized model of infiltrative glioma. We have used CNS-1 to study tumors that initiate within the brain parenchyma. The CNS-1 cells were stably transfected with the yellow fluorescent protein (YFP) variant Venus to enable standard one-photon a...

Primary lymphoma of the CNS (PCNSL) is a diffuse large B cell lymphoma confined to the CNS. To elucidate its peculiar organ tropism, we generated recombinant Abs (recAbs) identical to the BCR of 23 PCNSLs from immunocompetent patients. Although none of the recAbs showed self-reactivity upon testing with common autoantigens, they recognized 1547 proteins present on a large-scale protein microarr...

It is well established that the normal human brain contains populations of neural stem/progenitor cells. Recent studies suggest that they migrate toward a variety of CNS tissue injuries. In an investigation of the potential role of neural stem cells in the pathogenesis of primary CNS lymphomas (NHL-CNS), we observed that neural stem/progenitor cells appeared to accumulate at the border of the t...

Inflammatory myofibroblastic tumors (IMT) of the central nervous system (CNS) are rare entities that have a predilection for local recurrences. Approximately half of the inflammatory myofibroblastic tumors contain translocations that result in the over-expression of the anaplastic lymphoma kinase (ALK) gene. We hereby present the case of a patient diagnosed with a left parieto-occipital IMT tha...

Abstract Background CNS tumor registries (CTR) has evolved to a key tool for data collection, evaluation of diagnostic and treatment patients suffering from tumors the central nervous system (tCNS) in U.S, but CTR Africa does not yet exist. In comparison high-income countries (HIC), many low- middle-income (LMIC) do have national or registries. Furthermore, appropriate steps like MRI pathologic...