Combination chemotherapy in clinical practice has been generally accepted as a feasible strategy for overcoming multidrug resistance (MDR). Here, we designed and successfully prepared a co-delivery system named S-D1@L-D2 NPs, where denoted some smaller nanoparticles (NPs) carrying a drug doxorubicin (DOX) were loaded into a larger NP containing another drug (vincristine [VCR]) via water-in-oil-...

background: the increasing number of cesarean section is a great concern in many countries. in iran cesarean section rate has been steadily rising from 35% in 2000 to 40% in 2005. preferences for cesarean are often associated with some factors. objective: to investigate factors associated with preference for cesarean delivery, with special emphasis on pregnant women’s preferences in first pregn...

in this study, doxycycline hyclate release behavior from in situ forming drug delivery systems investigated. these systems based on poly()lactide-co-glycolide)(50:50 dissolved in n-methyl-2-pyrrolidone that were evaluated in different concentrations. these systems are useful for local treatment of periodontal diseases. uv spectroscopy is used to determine drug concentration in release medium. a...

a Research Soil Geographer, USDA-Agricultural Research Service, Jornada Experimental Range, MSC 3JER, NMSU, Box 30003, Las Cruces, NM 88003-8003, USA b College of Liberal Arts & Sciences, Roosevelt Hall, 1 Kellogg Circle, Emporia State University, Emporia, Kansas 66801, USA c Geosciences Department, University of West Georgia, Callaway Building, 1601 Maple Street, Carrollton, GA 30118, USA d De...

This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system....

Transdermal Drug Delivery In article 2300066, Canan Dagdeviren and co-workers report a soft, conformable embodiment of wearable ultrasound patch for transdermal delivery cosmeceuticals to the skin. The comprises 2D array bulk piezoelectric transducers embedded in poly(dimethylsiloxane) substrate. demonstrates 26.2-fold enhancement niacinamide porcine skin vitro with 10 min application.

This study aimed to modify the biological response of cells to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Super paramagnetic iron oxide nanoparticles (SPIONs) were prepared and used with gemcitabine (Gem). These two agents were encapsulated simultaneously intopoly (D, L-lactic-co-glycolic acid) (PLGA) to form multifunctional drug delivery system....

The combination of therapeutic nucleic acids and chemotherapeutic drugs has shown great promise for cancer therapy. In this study, asialoglycoprotein receptors (ASGPR) targeting-ligand-based liposomes were tested to determine whether they can co-deliver vimentin siRNA and doxorubicin to hepatocellular carcinoma (HCC) selectively. To achieve this goal, we developed an ASGPR receptor targeted co-...