During surface-initiated blood coagulation in vitro, activated factor XII (fXIIa) converts factor XI (fXI) to fXIa. Whereas fXI deficiency is associated with a hemorrhagic disorder, factor XII deficiency is not, suggesting that fXI can be activated by other mechanisms in vivo. Thrombin activates fXI, and several studies suggest that fXI promotes coagulation independent of fXII. However, a recen...

By T. HovIG, H. C. RowsELL, W. J. DODDS, L. J#{216}RGENSEN AND J. F. NIUSTARD I NVESTIGATIONS of hemostasis and thrombosis in the microcirculation of animals during the past century have provided considerable insight into the mechanisms 69, 15, 16,30,33,51 63,64,66 The vessel wall, platelets and blood coagulation are recognized to be important. Hughes3’ considered that the speed with which plat...

Coagulation testing is employed widely prior to open surgery and invasive procedures. This is based on the assumption that such testing is of clinical value in the prediction of bleeding. In order to improve the clinical understanding of the potential limitations of first-line coagulation tests used in this way, we have systematically reviewed the literature that addresses the value of routine ...

Neutrophil is a major player in the pathophysiology of severe sepsis. Recent studies have revealed that the cell death mechanism of neutrophils directly relates to the development of organ dysfunction during sepsis. Here we discuss about the different types of neutrophil cell death such as necrosis, apoptosis, autophagy, and the unique cell death style dubbed NETosis. NETosis cells release neut...

During surface-initiated blood coagulation in vitro, activated factor XII (fXIIa) converts factor XI (fXI) to fXIa. Whereas fXI deficiency is associated with a hemorrhagic disorder, factor XII deficiency is not, suggesting that fXI can be activated by other mechanisms in vivo. Thrombin activates fXI, and several studies suggest that fXI promotes coagulation independent of fXII. However, a recen...

Bleeding disorders can present at any age and vary in their severity. Haemophilia, which is characterised by its x-linked recessive inheritance, can present with a spontaneous mutation and therefore no family history will be evident. Three cases of trauma induced thigh haematomas as an initial presenting feature for people with haemophilia are discussed. The cases highlight the importance of a ...

CONTEXT There are contradictory results on the effect of hypothyroidism on the changes in hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). This paper reviews the studies on laboratory and population-based findings regarding hemostatic changes and risk of VTE in hypothyroidism and autoimmune thyroid disorders...

AIM To determine the frequency of inherited and acquired prothrombotic risk factors in children with arterial ischemic stroke (AIS) and transient ischemic attacks (TIA) in Croatia. METHODS We investigated 14 prothrombotic risk factors using blood samples from 124 children with AIS or TIA and 42 healthy children. Prothrombotic risk factors were classified into five groups: natural coagulation ...

Inhibitors to factor V is a rare phenomenon with varied clinical presentation ranging from asymptomatic states life-threatening bleeds. They are known be associated exposure bovine thrombin, drugs, autoimmune diseases and malignancies. Establishing the diagnosis of FV inhibitors challenging presence lupus-like properties inhibitor can further complicate diagnosis. Here we document an unusual ca...

The new coronavirus infection (currently classified as COVID-19), first identified in December 2019 Wuhan, China, has contributed to a significant increase global mortality. Coagulopathy is common disorder COVID-19 patients, which develops parallel with respiratory failure. Currently, continues be life-threatening disease and requires developments solutions define preventive curative strategies...