The blood is a very complex organ in our body and coagulation, in particular, is coordinated by various mechanisms. It is known from experience that in order to truly learn and comprehend the different coagulation processes and disorders, most medical students take much time and great pains. The topic is often regarded as not comprehensible and very abstract. This article is supposed to provide...

BACKGROUND AND PURPOSE In patients who present with acute ischemic stroke while on treatment with non-vitamin K antagonist oral anticoagulants (NOACs), coagulation testing is necessary to confirm the eligibility for thrombolytic therapy. We evaluated the current use of coagulation testing in routine clinical practice in patients who were on NOAC treatment at the time of acute ischemic stroke. ...

Bacterial endotoxins in vitro are capable of shortening the coagulation time of normal whole blood, native platelet-rich and platelet-poor plasma, and the blood of a hemophilic patient in silicone but not in glass. The point in the coagulation system at which the endotoxins act has not been found but the search has been narrowed by the demonstration that these materials act independently of leu...

The present study was performed to detect the usefulness of coagulation parameters that helps in the diagnosing the severity of changes associated with heat stroke. Twenty five previously healthy dogs with the history of epistaxis, hyperthermia and dyspnea after exposure to high environmental temperature were selected and subjected to detailed clinical examination, physical examination, laborat...

Factor X deficiency is a rare hereditary coagulation disorder. We report a case of congenital factor X deficiency diagnosed preoperatively in an 8-yr-old female child scheduled to undergo corrective surgery for congenital thoracolumbar kyphoscoliosis. Her preoperative coagulation profile revealed prolonged prothrombin time and activated partial thromboplastin time values. Further evaluation sho...

The coagulation process interpreted as a second order reaction and it is assumed that the intensity of scattered light on the colloidal particles follows the Raileygh eq. At each collision of two aggregates the smaller aggregate loses a given number of primary particles while the bigger aggregate increases by the same number of primary particles. The »critical time« (terit) is determined by the...

Each of several antigen-antibody systems studied has been found to affect the coagulation mechanism in the rabbit, causing a marked shortening of the coagulation time in vitro of samples of whole blood maintained in siliconized glassware. Addition of specific antigen to the blood of actively immunized animals or addition of antigen-antibody mixtures to the blood of normal animals produced the e...

An acquired formation of inhibitors to coagulation factors is a rare type of coagulopathy. The development of inhibitors for multiple coagulation factors has never been reported. A 75-year-old Japanese female underwent interventional therapy for hepatocellular carcinoma. Five days after the last intervention, her prothrombin time decreased to 10%, and her activated partial thromboplastin time (...

BACKGROUND Sickle cell anemia is associated with a hypercoagulable state that may lead to alterations in a coagulation profile. Measurements of coagulation factors are known to have some predictive value for clinical outcome. OBJECTIVES To determine the coagulation profile of children with SCA in steady state and crisis and compare it with those with normal HbAA genotype. MATERIALS AND METH...

A simple and affordable method of evaluating blood coagulation ability using microfluidic paperbased lateral flow assay (LFA) device is reported. Rabbit whole blood treated with citrate as anticoagulant was used in experiments. Re-establishment of blood coagulation cascade and creation of different coagulation abilities were achieved by adding CaCl2 solutions of varying concentrations. Since vi...