Cerebral venous sinus thrombosis (CVST) is an uncommon but life-threatening stroke subtype with extremely diverse clinical features, predisposing factors, brain imaging findings, and outcomes. Its predominant etiologies were known to be otomastoid, orbit, and central face cutaneous infections, pregnancy and complications associated with the postpartum period, and oral contraceptives. In recent ...

It is imperative for neurologists, neurosurgeons, and neurointensivists to know how to stop life-threatening hemorrhage in both surgical and non-surgical patients. However, knowing how to medically correct a coagulopathy has become increasingly challenging as more contemporary and sophisticated anticoagulation agents are developed and prescribed. In a time-sensitive and life-threatening situati...

the 2 components was considered as an indicator of prothrombotic tendency. We found values in patients with CC similar to those of Tripodi et al. [7], but patients with ACLF had significantly higher ratios (Table 2). The ratio in the patients with CC had a direct and significant correlation with the MELD score compared to the ACLF group in which the coagulopathic defects were more serious. In p...

Intracerebral haemorrhage is rare in childhood. We have reviewed the last 10 years' experience, in our referral area, of parenchymatous intracerebral haemorrhage in children from 1 month to 16 years of age. There were 27 cases, five of which were intracerebellar and two predominantly intraventricular. The commonest aetiology was vascular malformation (10), followed by haemorrhage into tumour (f...

Background: Schwannomas are the most common extramedullary spinal tumors. The acute hemorrhagic onset of a spinal schwannoma is a rare occurrence. Case report: We report the case of a 32-year-old woman who presents with acute onset of quadriparesis due to a hemorrhagic intradural schwannoma. The tumor arose from left C1-C2 roots and extended downward from C1 to C5 vertebral levels. An emergency...

Dysfunctional uterine bleeding is very common in adolescents because of the high frequency of anovulatory cycles in this age group. The diagnosis of dysfunctional uterine bleeding is based on the exclusion of all the other causes of abnormal uterine bleeding in an adolescent. The most common causes of abnormal uterine bleeding include coagulopathies, pregnancy, trauma, and endocrinopathies. Men...

Von Willebrand's disease is the most common hereditary coagulation disorder in young women. This report aimed at describing the case of obese patient with von Willebrand's disease scheduled for cesarean section. We report the case of an obese patient, 26 years old, with von Willebrand's disease, admitted to the emergency room in early labor. Cesarean section was indicated because the baby shows...

Neutropenic enterocolitis (NEC) is a life-threatening disease with substantial morbidity and mortality, seen primarily in patients with hematologic malignancies. The frequency of NEC has increased with the widespread use of chemotherapeutic agents such as the taxanes, which cause severe gastrointestinal mucositis. Neutropenic patients with fever and abdominal symptoms (cramping, pain, distentio...

The diagnostic and therapeutic utility of flexible fibreoptic bronchoscopy (FFB), coupled with its minimal morbidity and mortality, have led to its increasing use in the care of the critically ill patients. FFB allows direct inspection of the upper and lower airway, and facilitates the diagnosis and management of a variety of pulmonary disorders. Patients in the intensive care unit are predispo...

Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed using 33 proteomic datasets and 354 literature references. The network contains enzymes mapping to 403 diseases and 231 FDA approved drugs, al...