Modern science of networks has brought significant advances to our understanding of complex systems biology. As a representative model of systems biology, Protein Interaction Networks (PINs) are characterized by a remarkable modular structures, reflecting functional associations between their components. Many methods were proposed to capture cohesive modules so that there is a higher density of...

During DNA replication by the λ-like bacteriophages, immature concatemeric DNA is produced by rolling circle replication. The concatemers are processed into mature chromosomes with cohesive ends, and packaged into prohead shells, during virion assembly. Cohesive ends are generated by the viral enzyme terminase, which introduces staggered nicks at cos, an approx. 200 bp-long sequence containing ...

This study attempts to model sediment transport rates and the resulting bed evolution in a complex estuarine environment: the Gironde estuary, characterized by a high hetereogeneity in the sediment bed composition, with the presence of both cohesive and non-cohesive sediments and sand/mud mixtures. Our main objective is to extend an existing 2D morphodynamic model developped by Huybrechts et al...

Social action is situated in fields that are simultaneously composed of interpersonal ties and relations among organizations, which are both usefully characterized as social networks. We introduce a novel approach to distinguishing different network macro-structures in terms of cohesive subsets and their overlaps. We develop a vocabulary that relates different forms of network cohesion to field...

Revealing functional units in protein-protein interaction (PPI) networks are important for understanding cellular functional organization. Current algorithms for identifying functional units mainly focus on cohesive protein complexes which have more internal interactions than external interactions. Most of these approaches do not handle overlaps among complexes since they usually allow a protei...

Young infants construct models of the world composed of objects tracked through time and occlusion. To date little is known about the degree to which these models are sensitive to the material makeup of the represented individuals. Two experiments probed 8-month-olds’ ability to represent different kinds of entities: rigid, cohesive objects, flexible, cohesive objects, and non-rigid, non-cohesi...

Massively parallel finite element simulations of dynamic fracture and fragmentation of brittle solids are presented. Fracture is introduced by the adaptive insertion of cohesive elements. The model is validated against specially designed experiments in a collaborative effort between the experimental and the computational groups. Mesh sensitivity issues are addressed through the renormalization ...

An incremental symmetric boundary integral formulation for the problem of many domains connected by non-linear cohesive interfaces is here presented. The problem of domains with traction-free cracks and/or rigid connections are particular instances of the proposed cohesive formulation. The numerical approximation of the considered problem is achieved by the symmetric Galerkin boundary element m...

Conventional fracture closure models typically assume homogeneous formation. This assumption renders complex pressure analysis during shut-in insufficient at present. In this paper, we use a cohesive zone method (CZM)-based finite element model to obtain the and minimum horizontal principal stress of major branch based on fall-off analysis. Key factors including leak-off rate, injection time, a...

ICICLE (Interactive Computer Identi cation and Correction of Language Errors) is a tutoring system under development that instructs deaf users of American Sign Language on written English skills. (See (McCoy & Masterman (Michaud) 1997) for a discussion of overall system architecture.) The text generation module it will employ produces original text to instruct the user on errors found in his or...