The original observation that in wild-type colicinogenic Escherichia coli strains the introduction of some R factors abolish their colicin production was studied in certain col(+) strains bearing well-defined col factors. Two resistance (R) factors were used and introduced by conjugation in these strains, namely the 222 factor of Watanabe and a Salmonella typhimurium ST factor (coding for resis...

BACKGROUND Several studies have reported that colchicine attenuated the infarct size and inflammation in acute myocardial infarction (MI). However, the sustained benefit of colchicine administration on survival and cardiac function after MI is unknown. It was hypothesized that the short-term treatment with colchicine could improve survival and cardiac function during the recovery phase of MI.Me...

The increase in human leukocyte adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels seen in response to various substances was markedly potentiated by colchicine and other agents that affect microtubule assembly. Addition of dl-isoproterenol (2 muM) or prostaglandin E(1) (10 muM), together with the phosphodiesterase inhibitor isobutylmethylxanthine (1 mM), caused a much greater increase in...

The aim of this study was to determine whether colchicine, which has been reported to protect against various hepatotoxic insults, influences the susceptibility of mice to the agonistic anti-Fas antibody, Jo2. All mice that were pretreated with colchicine (2 mg/kg) survived the lethal challenge of intraperitoneal administration of 10 microg of Jo2, whereas all control mice pretreated with gamma...

Colchicine is a microtubule disruptor that reduces the occurrence of atrial fibrillation (AF) after an operation or ablation. However, knowledge of the effects of colchicine on atrial myocytes is limited. The aim of this study was to determine if colchicine can regulate calcium (Ca(2+) ) homeostasis and attenuate the electrical effects of the extracellular matrix on atrial myocytes. Whole-cell ...

INTRODUCTION In spite of being the fastest acting drug available for the control of an acute gout attack, colchicine is generally considered a last alternative in gout therapy. This is mainly due to the severe adverse effects associated with its administration through the enteral and parenteral routes, as well as its high risk/benefit ratio. The preparation of dosage forms of colchicine that ca...

Recovery from destruction by sodium deoxycholate (DOC) was studied with the receptor membrane of the blowfly, Phormia regina. The recovery can be divided into two processes, colchicine dependent and colchicine independent. The colchicine-dependent process was completely depressed by pretreatment with colchicine at 5 mM for 2 min (partially at 0.1 mM for 10 min), but the colchicine-independent o...

1866 to July, 1867.-Surgeon-General Sir 'William Guyer Hunter, M.D., F.R.C.S.E. July, 1867 to January, 1872.-Major J. H. Sylvester, M.R.C.S., F.G.C. January 28, 1872 to May 31, 1895.-Brigade Surgeon Lt.-Col. George Archibald Maconachie, M.D., C.M. (Aber.). June 1, 1895 to April 19, 1907.-Lt.-Col. H. Herbert, I.M.S. April 20, 1907 to February 28, 1914.-Lt.-Col. P. P. IKilkelly, M.B., I.M.S. Marc...

1866 to July, 1867.-Surgeon-General Sir 'William Guyer Hunter, M.D., F.R.C.S.E. July, 1867 to January, 1872.-Major J. H. Sylvester, M.R.C.S., F.G.C. January 28, 1872 to May 31, 1895.-Brigade Surgeon Lt.-Col. George Archibald Maconachie, M.D., C.M. (Aber.). June 1, 1895 to April 19, 1907.-Lt.-Col. H. Herbert, I.M.S. April 20, 1907 to February 28, 1914.-Lt.-Col. P. P. IKilkelly, M.B., I.M.S. Marc...