Ullrich Congenital Muscular Dystrophy (UCMD), Bethlem Myopathy (BM), and Congenital Myosclerosis are diseases caused by mutations in the genes encoding the extracellular matrix protein collagen VI. A dystrophic mouse model, where collagen VI synthesis was prevented by targeted inactivation of the Col6a1 gene, allowed the investigation of pathogenesis, which revealed the existence of a Ca(2+)-me...

Metarhizium anisopliae is a well-studied entomopathogenic fungus that widely used in biological control programs. The presence of polymycoviruses this common, but their effects on fungal development and stress tolerance are not well understood. In study, we report the discovery novel double-stranded RNA virus, named polymycovirus 1 (MaPmV1), which comprises four dsRNAs ranging from 2.4 to 1.4 k...

BACKGROUND TMPRSS2:ERG fusions are promising prostate cancer biomarkers. Because they can occur in multiple forms in a single cancer specimen, we developed a quantitative PCR test that detects both type III and type VI TMPRSS2:ERG fusions. The assay is quantified from a standard curve determined with a plasmid-cloned type III TMPRSS2:ERG fusion target. METHODS We collected expressed prostatic...

Hexavalent chromium (Cr(VI)) compounds are confirmed human carcinogens for lung cancer. Our previous studies has demonstrated that chronic exposure of human bronchial epithelial BEAS-2B cells to low dose of Cr(VI) causes malignant cell transformation. The acquisition of cancer stem cell-like properties is involved in the initiation of cancers. The present study has observed that a small populat...

OBJECTIVE Ullrich congenital muscular dystrophy (UCMD) corresponds to the severe end of the clinical spectrum of neuromuscular disorders caused by mutations in the genes encoding collagen VI (COL VI). We studied four unrelated families with six affected children that had typical UCMD with dominant and recessive inheritance. MATERIALS & METHODS Four unrelated Iranian families with six affected...

Vibrio harveyi is one of the major pathogens in aquaculture. To identify key virulence factors affecting pathogenesis V. towards fish, we conducted a field investigation for three representative fish farms infected with harveyi. Multilocus sequence typing (MLST) and whole-genome sequencing were to delineate phylogenetic relationship genetic divergence A total 25 strains isolated from diseased g...

The voltammetric characteristics of Mo (VI) oxinate at the mercury electrode, in the presence of tri-butylammonium perchlorate (tri-BAP) and piperidinium perchlorate (PP) + piperidine (P) as  two different types supporting electrolytes, have been studied in chloroform. With the both supporting electrolytes a two electron irreversible process for the reduction  of Mo (VI) oxinate was observe...