The biogenesis of dense-core secretory granules (DCGs), organelles responsible for the storage and secretion of neurotransmitters and neuropeptides in chromaffin cells, is poorly understood. Chromogranin A (CgA), which binds catecholamines for storage in the lumen of chromaffin granules, has been shown to be involved in DCG biogenesis in neuroendocrine PC12 cells. Here, we report that downregul...

Background: Hospitalization has been widely accepted for elderly patients with acute or chronic disease. However, hospitalization is also thought to be a risk factor for delirium in hospitalized elderly patients The aim of this study is to assess the efficiency of Comprehensive Geriatric Assessment (CGA) nursing strategy for elderly patients with Coronary Heart Disease (CHD) during hospitalizat...

The health benefit of coffee consumption mainly depends on chlorogenic acid (CGA), one its major active phenolic constituent. CGA have several biological properties like anticancer, antihypertensive, hepatoprotective, neuroprotective, renoprotective, antimicrobial etc. It is assumed that different forms contains amount CGA. In this regards, we developed and validated a simple cost effective chr...

Chlorogenic acid (CGA) is widely distributed in the plant kingdom.For example, green coffee beans contain 6–10% CGA, and a 200-ml cup of coffee may have 20–675 mg CGA, depending on the roasting and brewing conditions [1]. In potato tubers CGA constitutes up to 90% of the total phenolic content [2]. CGAplays an important role in Progr Colloid Polym Sci (2004) 127: 83–88 DOI 10.1007/b98017 Spring...

BACKGROUND As a consequence of demographic changes, hospitals are confronted with increasing numbers of elderly patients, who are at high risk of adverse events during hospitalization. Geriatric risk screening followed by comprehensive geriatric assessment (CGA) and treatment has been requested by geriatric societies and task forces to identify patients at risk. Since empirical evidence on fact...

"There appears to be a direct correlation between tumor burden and serum CgA levels. Rising serum levels of CgA can predeed radiographic evidence of recurrence. . . . .Using serum CgA level above 30 U/ml, one is able to discriminate between disease free patients and those with recurrent metastatic disease with a sensitivity of 92% and specificity of 96%. This is superior to measuring urinary 5-...

BACKGROUND prognostication for frail older adults is complex, especially when they become seriously ill. OBJECTIVES to test the measurement properties, especially the predictive validity, of a frailty index based on a comprehensive geriatric assessment (FI-CGA) in an acute care setting in relation to the risk of death, length of stay and discharge destination. DESIGN AND SETTING prospective...

Regular coffee consumption significantly lowers the risk of type 2 diabetes (T2D). Coffee contains thousands of compounds; however, the specific component(s) responsible for this reduced risk is unknown. Chlorogenic acids (CGA) found in brewed coffee inhibit intestinal glucose uptake in vitro. The objective of this study was to elucidate the mechanisms by which CGA acts to mediate blood glucose...

BACKGROUND Risk assessments of patients should be based on objective variables, such as biological markers that can be measured routinely. The acute response to stress causes the release of catecholamines from the adrenal medulla accompanied by chromogranin A (CGA). To date, no study has evaluated the prognostic value of CGA in critically ill intensive care unit patients. METHODS We conducted...

BACKGROUND comprehensive geriatric assessment (CGA) appears to be less effective when performed in outpatient clinics than in hospital settings. The effectiveness of outpatient CGA might be improved by selectively targeting frailer community-dwelling elderly people. The purpose of this study was to evaluate the clinical performance of rapidly-administered standard screening measures for geriatr...