background: colorectal cancer is one of the most common malignancies worldwide with more than one million new cases diagnosed each year . the aim of this study is to investigate the prevalence of herpes simplex virus and epstein-barr virus in patients with colorectal carcinomas and polyps in comparison with healthy subjects by using the polymerase chain reaction technique. methods: in this anal...

Two main hereditary colorectal cancer syndromes have been described, namely familial adenomatous polyposis coli (FAP) and hereditary non-polyposis colorectal cancer (HNPCC). FAP is a disease characterised by autosomal dominant inheritance where the affected subjects develop hundreds to thousands of adenomatous polyps throughout the whole colon, usually during their teenage years. This syndrome ...

Desmogleins are glycoproteins of the desmosomes squamous epithelia. To understand roles desmogleins (Dsgs) 1 and 3 in cancer, tissue microarrays containing 16,100 samples from 138 different tumour types were analysed by IHC. Dsg1 Dsg3 staining was detectable 39 (28%) 49 (36%) categories. Four 12 cell cancer showed ≥90% positivity for and/or Dsg3, another 7 SQCC 80–89% positivity. also found bas...

Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 is involved in calcium mobilization from the endoplasmic reticulum into the cytosol and is closely linked to metabolism, neuronal plasticity, gene transcription, cell growth, differentiation, apoptosis, protein folding and carcinogenesis. In order to elucidate the role of SERCA3 in colorectal carcinogenesis and subsequent progression, its expres...

Knowledge of intrinsic tumor heterogeneity is vital for understanding of tumor progression mechanisms as well as for providing efficient treatments. In situ proteomic profiling of tumors is a powerful technology with potential to enhance our understanding of tumor biology, but sources of variability due to patient and tumor heterogeneity are poorly understood and are the topic of this investiga...

Colorectal cancer is one of the most common cancers in many countries, including Malaysia. The accumulation of genomic alterations is an important feature of colorectal carcinogenesis. A better understanding of the molecular events underlying the stages of colorectal carcinogenesis might be helpful in the detection and management of the disease. We used a commercially available single-nucl...

Endoscopic treatment for early colorectal cancer closely correlates with patient prognosis. However, endoscopic differentiation between carcinomas and non-neoplastic lesions remains difficult. Here, we topically stained colorectal neoplasms with a fatty acid analogue (BODIPY-FA) and quantified the fluorescent signals using confocal laser endomicroscopy (CLE) and fluorescence microscopy. We also...