Background. There is to our knowledge metabolic changes induced by combined oral contraceptives (COC) use in regularly active females. Objectives. Analyzing blood cortisol and other biochemical variables in active (COC) users and non-users. Methods. A total of 123 active female students (25 COC users and 98 non-users) volunteered to participate in the study.  The COC users declared 2-3 years ...