نتایج جستجو برای: compound enhancement

تعداد نتایج: 253678  

2016
Irfana Muqbil Amro Aboukameel Sivan Elloul Robert Carlson William Senapedis Erkan Baloglu Michael Kauffman Sharon Shacham Divaya Bhutani Jeffrey Zonder Asfar S. Azmi Ramzi M. Mohammad

In previous studies we demonstrated that targeting the nuclear exporter protein exportin-1 (CRM1/XPO1) by a selective inhibitor of nuclear export (SINE) compound is a viable therapeutic strategy against Non-Hodgkin Lymphoma (NHL). Our studies along with pre-clinical work from others led to the evaluation of the lead SINE compound, selinexor, in a phase 1 trial in patients with CLL or NHL (NCT02...

Journal: :The Journal of biological chemistry 1992
W J Chuang H E Van Wart

The nature of the porphyrin pi-cation radicals in the horseradish peroxidase and bovine liver catalase (BLC) compound I species have been investigated by studying their resonance Raman spectra. A variety of laser excitation and sample interrogation procedures have been employed in order to minimize previously documented problems arising from photoinduced conversions. With Soret band excitation,...

2005
ATANAS V. KOULOV ROGER G. HANSHAW KENNETH A. STUCKER C. LAKSHMI BRADLEY D. SMITH

A Zn-dipicolylamine coordination compound is shown to sense the presence of anionic phospholipids in a membrane bilayer. The sensor contains two dipicolylamine subunits attached to an anthracene scaffold, which exhibits a maximum absorbance at 380 nm, and undergoes an enhancement in fluorescence intensity when exposed to membranes enriched in phosphatidylserine. For these reasons, the compound ...

Journal: :Molecular and cellular biology 1999
M L Holmes J D Haley L Cerruti W L Zhou H Zogos D E Smith J M Cunningham S M Jane

A fungus-derived compound (OSI-2040) which induces fetal globin expression in the absence of erythroid cell differentiation was identified in a high-throughput drug discovery program. We utilized this compound to isolate gamma-globin regulatory genes that are differentially expressed in OSI-2040-induced and uninduced cells in the human erythroleukemia cell line K562. Representational difference...

2015
Kiran Sharma Ashu Mittal Nitesh Chauhan

Corresponding Authors: Kiran Sharma II E 96 / A, Nehru nagar, Ghaizabad, 201001, U.P. Email id: [email protected] Abstract: Skin penetration enhancers are the most commonly used approach for enhancing drug penetration into the skin through transdermal drug delivery system or topical administration. These skin penetration enhancers are molecules which reversibly remove the barrier resistance...

Journal: :iranian journal of pharmaceutical research 0
hadi fathi-moghaddam depattment of physiology and physiology research center, school of medicine, jondishapour university of medical sciences, ahwaz, iran. mehdi shafiee ardestani department of hiv and hepatitis b and nanobiotechnology,pasteur institute of iran, tehran, iran. mostafa saffari department of pharmaceutics, faculty of pharmacy, shahid beheshti university of medical sciences, tehran, iran. ali jabbari arabzadeh depattment of physiology and physiology research center, school of medicine, jondishapour university of medical sciences, ahwaz, iran. mitra elmi department of pharmacology, razi institute for drug research, college of medicine, iran university of medical sciences, tehran, iran.

a substantial amount of evidence has proposed an important role for cyclooxygenase-2 (cox-2) enzyme in brain diseases and affiliate disorders. the purpose of this research was studying the effects of cox-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and parkinson’s disease (pd). in this study, the effect of acute and sub-chronic oral administration ...

Journal: :iranian journal of public health 0
i. farahmandian f. arfaa sh. keyvan m. sohrabi

in the course of an evaluation of various schistosomicidal drugs in iran, the effect of an organo-phosphorus compound in the-treatment of 45 mild cases of urinary bilhariziasis was assessed and the drug was given in 3 doses of 10 mg/kg body weight each with 3-week intervals. follow-up examinations undertaken 3 weeks after the 1st, 2nd and 3rd doses as well as 3 months after completion of therap...

Journal: :iranian journal of catalysis 2013
marziyeh bagheri mostafa karimkoshteh

nano silica-h2so4 is an efficient and mild catalysis system for the regeneration of aldehyde from aldoximes. ketoximes are converted to amides by beckmann rearrangement in the presence of nano silica-h2so4. the reactions are carried out in solvent-free conditions under microwave irradiation (600 w) within 50-120 sec in good yields.

Journal: :progress in biological sciences 2013
bahareh nowruzi ramazan ali khavari-nejad karina sivonen bahram kazemi farzaneh najafi

cyanobacteria are well known for their production of a multitude of highly toxic substances . the genus stigomena is regarded as good candidates for producing biologically active secondary metabolites, which are highly toxic to humans and other animals. the carcass of a dog was found at the shore of lake ali-abad, iran. biomass from the discovery site appeared to be of cyanobacterial nature. we...

Journal: :American journal of physiology. Endocrinology and metabolism 2008
Helen Cho Shawn C Black David Looper Manli Shi Dawn Kelly-Sullivan Sergei Timofeevski Karen Siegel Xiao-Hong Yu Scott R McDonnell Ping Chen Junming Yie Kathleen M Ogilvie James Fraser Celia P Briscoe

c-Jun NH(2)-terminal kinase (JNK) plays an important role in insulin resistance; however, identification of pharmacologically potent and selective small molecule JNK inhibitors has been limited. Compound A has a cell IC(50) of 102 nM and is at least 100-fold selective against related kinases and 27-fold selective against glycogen synthase kinase-3beta and cyclin-dependent kinase-2. In C57BL/6 m...

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